Radiation-killed bacteria vaccine created

Jul 25, 2006

U.S. scientists say vaccines made with bacteria killed by gamma irradiation, rather than by heat or chemical inactivation, may be more effective.

Researchers supported by the U.S. National Institute of Allergy and Infectious Diseases say vaccines made from gamma-irradiated bacteria also might not need to be kept cold -- an advantage in settings where refrigerating vaccines is impractical or impossible.

In experiments with mice, scientists including Eyal Raz, Sandip Datta and Joshua Fierer of the University of California-San Diego School of Medicine demonstrated a vaccine made from irradiated Listeria monocytogenes bacteria -- unlike a vaccine made from heat-killed bacteria -- provides protection against live Listeria.

The irradiated bacteria also stimulated a protective response from immune system cells called T cells. Previously, only vaccines made from live, weakened Listeria bacteria were believed capable of eliciting a T-cell response.

A report on the research appears in the current issue of the journal Immunity.

Copyright 2006 by United Press International

Explore further: Ebola reveals shortcomings of African solidarity

add to favorites email to friend print save as pdf

Related Stories

Quest to unravel mysteries of our gene network

Dec 18, 2014

There are roughly 27,000 genes in the human body, all but a relative few of them connected through an intricate and complex network that plays a dominant role in shaping our physiological structure and functions.

Recommended for you

Ebola-hit Liberia delays school reopening

5 hours ago

Liberia's education ministry said on Sunday it had postponed by two weeks the reopening of the country's schools, which were closed six months ago to limit the spread of the Ebola virus.

Ebola: timeline of a ruthless killer

14 hours ago

Here are key dates in the current Ebola epidemic, the worst ever outbreak of the haemorrhagic fever which first surfaced in 1976 in the Democratic Republic of Congo (DRC).

Chile's Bachelet sends abortion bill to Congress

14 hours ago

Chile's President Michelle Bachelet on Saturday pressed ahead with plans to decriminalize abortion in certain cases, a decades-old taboo in one of Latin America's most socially conservative countries.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.