Study may help prevent bioterrorism

Jul 24, 2006

U.S. scientists say they've shown a protein in the nucleus of smallpox victims' cells triggers progression of smallpox-related illnesses.

The Purdue University researchers say their landmark finding might help prevent the use of such viruses as bioterrorism weapons.

The researchers found that poxviruses move to the second and third stages of development by recruiting a protein, called TATA-binding protein, in the nucleus of mammals' cells.

"This protein is required for activation of the middle- and late-stage poxvirus genes," said Steven Broyles, a Purdue biochemistry professor. "In the past, we were just groping around. We now have a model for how the poxvirus growth process is orchestrated."

The research is published in the current issue of the Journal of Virology.

Copyright 2006 by United Press International

Explore further: Patients who have left breast tumors have comparable OS to those with right breast tumors

add to favorites email to friend print save as pdf

Related Stories

Virus exploitscellular waste disposal system

Oct 19, 2012

ETH Zurich researchers demonstrate how vaccinia virus manipulates the cellular waste-disposal system and thereby cleverly tricks the cell into assisting the intruders replication. Now, the virologists have ...

The unexpected relatives of smallpox

Sep 09, 2011

(PhysOrg.com) -- A protein shared by the simple viruses that infect single-cell organisms, and their highly complex counterparts that affect mammals, could hold to the key to understanding and ultimately neutralising ...

Avian flu vaccine on the brink

Jan 10, 2011

A collaboration between BBSRC and STFC-funded scientists has been using a new form of low energy microscopy to observe how poxviruses interact with components inside live cells. Genetically modified fowlpox ...

Scientists identify antivirus system

Nov 17, 2010

(PhysOrg.com) -- Viruses have led scientists at Washington University School of Medicine in St. Louis to the discovery of a security system in host cells.

Will monkeypox be the next smallpox?

Sep 28, 2010

Most vertebrate animal species have some sort of poxvirus capable of causing severe illness. These ancient pathogens have evolved within and among vertebrates since the dawn of life. In one of public health's greatest ...

Recommended for you

New research software automates DNA analysis

8 minutes ago

At the core of medical research is problem-solving, which is exactly what two PhD scientists did when they set out to eliminate a common, time-consuming task performed in research laboratories around the world.

Supercomputers link proteins to drug side effects

9 minutes ago

New medications created by pharmaceutical companies have helped millions of Americans alleviate pain and suffering from their medical conditions. However, the drug creation process often misses many side ...

Ebola: Five questions about the killer virus

15 minutes ago

The highly contagious Ebola virus, which has killed more than 4,500 people in west Africa since December and has fueled global alarm, is among the most dangerous ever identified.

User comments : 0