Study predicts, verifies protein folding

Oct 04, 2005

Houston scientists have combined theory and experiment for the first time to predict and verify protein-folding dynamics of a complex protein.

"Researchers have successfully combined computer modeling and experimental results in folding studies for small proteins, but this is the first effective combination for a large, multi-domain protein," said study co-author Kathleen Matthews, dean of Rice University's Wiess School of Natural Sciences.

Each cell in the human body contains thousands of proteins. A protein's function is tied to shape and every protein self-assembles into its characteristic shape within seconds of being created.

"The folded, functional form of the protein is what really matters, and our interest is in creating a folding roadmap of sorts, a plot of the thermodynamic route that the protein follows as it moves toward equilibrium," said co-author Cecilia Clementi, an assistant professor of chemistry.

The research appears in the Proceedings of the National Academy of Sciences.

Copyright 2005 by United Press International

Explore further: When identity marketing backfires: Consumers don't like to be told what they like

add to favorites email to friend print save as pdf

Related Stories

Activating ALC1: With a little help from friends

Nov 29, 2012

Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell ...

Recommended for you

Online reviews: When do negative opinions boost sales?

12 hours ago

When purchasing items online, reading customer reviews is a convenient way to get a real-world account of other people's opinions of the product. According to a new study in the Journal of Consumer Research, negative review ...

User comments : 0

More news stories

Online reviews: When do negative opinions boost sales?

When purchasing items online, reading customer reviews is a convenient way to get a real-world account of other people's opinions of the product. According to a new study in the Journal of Consumer Research, negative review ...

Low Vitamin D may not be a culprit in menopause symptoms

A new study from the Women's Health Initiative (WHI) shows no significant connection between vitamin D levels and menopause symptoms. The study was published online today in Menopause, the journal of The North American Menopa ...

Astronomers: 'Tilt-a-worlds' could harbor life

A fluctuating tilt in a planet's orbit does not preclude the possibility of life, according to new research by astronomers at the University of Washington, Utah's Weber State University and NASA. In fact, ...