National Jewish Health receives patent for liposome-based vaccine

Sep 27, 2010

(PhysOrg.com) -- National Jewish Health has received a US patent for a new kind of vaccine, which uses a small lipid bubble to deliver an antigen and DNA adjuvant.

Chairman of Pediatrics Erwin Gelfand, MD, and former National Jewish Health Professor of Medicine Steve Dow, PhD, developed the new liposome-based adjuvant.

Live vaccines, containing weakened forms of an infectious organism, generally work fine by themselves. But vaccines containing dead organisms or pieces of the infectious organisms or their toxins generally need adjuvants to boost their effectiveness. Aluminum salts, known as alum, are the most common adjuvant used in the United States for routine preventive vaccines.

The recently patented invention by Drs. Gelfand and Dow describes a contained within a liposome, a tiny vesicle made of a double layer of lipids. Contained within the liposome is a DNA sequence that serves as an adjuvant. Depending on the sequence, either the DNA molecule itself or the protein for which it codes can be used to stimulate the immune system. This is fused to an immunogen, the protein fragment against which the immune mounts a specific attack. The protein fragment could be part of an infectious organism or possibly some other health hazard such as a cancer tumor. The liposome-based vaccine could be delivered either subcutaneously through injection or orally.

The patent, #7741300, (patft.uspto.gov/netacgi/nph-Pa… 741300&RS=PN/7741300) is currently licensed to a US biotechnology company for commercial development.

Explore further: Combining epilepsy drug, morphine can result in less pain, lower opioid doses

Provided by National Jewish Health

not rated yet
add to favorites email to friend print save as pdf

Related Stories

New 'adjuvant' could hold future of vaccine development

Sep 14, 2009

Scientists at Oregon State University have developed a new "adjuvant" that could allow the creation of important new vaccines, possibly become a universal vaccine carrier and help medical experts tackle many diseases more ...

Tattooing improves response to DNA vaccine

Feb 07, 2008

A tattoo can be more than just a fashion statement – it has potential medical value, according to an article published in the online open access journal, Genetic Vaccines and Therapy.

Recommended for you

Vaccine proves effective against deadly Middle East virus

Sep 15, 2014

(Medical Xpress)—A vaccine developed by an international team of scientists led by the University of Pittsburgh School of Medicine successfully protects mice against a contagious and deadly virus spreading across the Middle ...

New study looks at improving vaccine awareness

Sep 15, 2014

The best medical therapies won't do much good if the public abstains from using them. Resistance to life-saving interventions may have a variety of root causes, particularly if the biotechnology involved is new and poorly ...

High-dose opioid prescribing continues to climb

Sep 12, 2014

High-dose opioid prescribing increased by 23 per cent in Canada between 2006 and 2011, despite clinical guidelines recommending that most patients should avoid high-doses of these drugs, according to new ...

Feds say Bayer colon supplement makes bogus claims

Sep 12, 2014

The United States government accused Bayer of making scientifically unproven statements about the health benefits of a popular probiotic on Friday, claiming the German pharmaceutical giant was in contempt of court.

User comments : 0