National Jewish Health receives patent for liposome-based vaccine

Sep 27, 2010

(PhysOrg.com) -- National Jewish Health has received a US patent for a new kind of vaccine, which uses a small lipid bubble to deliver an antigen and DNA adjuvant.

Chairman of Pediatrics Erwin Gelfand, MD, and former National Jewish Health Professor of Medicine Steve Dow, PhD, developed the new liposome-based adjuvant.

Live vaccines, containing weakened forms of an infectious organism, generally work fine by themselves. But vaccines containing dead organisms or pieces of the infectious organisms or their toxins generally need adjuvants to boost their effectiveness. Aluminum salts, known as alum, are the most common adjuvant used in the United States for routine preventive vaccines.

The recently patented invention by Drs. Gelfand and Dow describes a contained within a liposome, a tiny vesicle made of a double layer of lipids. Contained within the liposome is a DNA sequence that serves as an adjuvant. Depending on the sequence, either the DNA molecule itself or the protein for which it codes can be used to stimulate the immune system. This is fused to an immunogen, the protein fragment against which the immune mounts a specific attack. The protein fragment could be part of an infectious organism or possibly some other health hazard such as a cancer tumor. The liposome-based vaccine could be delivered either subcutaneously through injection or orally.

The patent, #7741300, (patft.uspto.gov/netacgi/nph-Pa… 741300&RS=PN/7741300) is currently licensed to a US biotechnology company for commercial development.

Explore further: EU regulator: Morning-after pill OK for all women

Provided by National Jewish Health

not rated yet
add to favorites email to friend print save as pdf

Related Stories

New 'adjuvant' could hold future of vaccine development

Sep 14, 2009

Scientists at Oregon State University have developed a new "adjuvant" that could allow the creation of important new vaccines, possibly become a universal vaccine carrier and help medical experts tackle many diseases more ...

Tattooing improves response to DNA vaccine

Feb 07, 2008

A tattoo can be more than just a fashion statement – it has potential medical value, according to an article published in the online open access journal, Genetic Vaccines and Therapy.

Recommended for you

EU regulator: Morning-after pill OK for all women

10 hours ago

(AP)—A commonly used morning-after pill is suitable for use by heavier women, the European Medicines Agency said Thursday after a review of the evidence sparked by the French manufacturer's declaration that the drugs didn't ...

Physicians warned about counterfeit medical devices

14 hours ago

(HealthDay)—Physicians should be aware of the prevalence and serious consequences associated with use of counterfeit medical devices, according to a letter to the editor published online July 20 in Lasers in ...

Zydelig approved for three types of blood cancer

15 hours ago

(HealthDay)—Zydelig (idelalisib) has been approved by the U.S. Food and Drug Administration to treat relapsed forms of blood cancer, including chronic lymphocytic leukemia (CLL), follicular B-cell non-Hodgkin lymphoma (FL) ...

Journal raises concern about blood-thinning drug

Jul 23, 2014

A medical journal raised concerns Wednesday about a blood-thinning drug widely used by people at risk of stroke, accusing its manufacturer of concealing safety data and regulators of laxness.

User comments : 0