Soluble amyloid beta-protein implicated in Alzheimer's disease

Sep 02, 2010

Alzheimer's disease (AD) is the most common human dementia and as such confers a huge burden on patients, caregivers and society. The molecular pathways leading to AD are not well understood, but substantial data indicate that the amyloid β-protein (Aβ) plays a central role.

The steady state level of Aβ is controlled by its production, degradation and clearance and it is proposed that in disease a defect leading to over-production or decreased clearance causes an accumulation of Aβ. This in turn triggers a pathogenic cascade culminating in the cognitive deficits that characterise AD.

Like several other disease-associated proteins, Aβ has the ability to self-associate, and can form an array of different assembly forms ranging from individual monomers to large insoluble aggregates known as amyloid plaques.

Since plaques are pathologic hallmarks of AD it had been assumed that they also caused the disease. However, the quantity and temporal progression of amyloid plaques do not correlate well with disease status, thus raising the simple question: if Aβ causes AD, then why doesn't the amount of Aβ in the form of plaques relate to the severity of ?

Studies recently published in Brain by the group of Conway Fellow, Professor Dominic Walsh, looked at the relationship between various biochemical forms of Aβ and the presence of AD-type dementia.

Using 43 brains from the MRC Cognitive Function and Ageing Study, the Conway-based group examined the relationship between biochemically distinct forms of Aβ and the presence of dementia. Analysis revealed that the level of SDS-stable Aβ dimers in strongly correlated with the presence of AD-type dementia.

These exciting findings build on earlier publications from the Walsh group that SDS-stable Aβ dimers can impair neuronal functions necessary for memory formation and suggest that targeting Aβ dimers may alleviate the memory loss typical of AD.

A follow-up study looking at the relationship between biochemically distinct forms of Aβ and AD-type dementia in 220 brains was recently funded to the tune of €550,000 by the MRC and should allow for further validation of Aβ dimers as mediators of disease. Parallel studies (funded by NIH, EU, SFI and HRB) aimed at developing antibodies and small molecules which bind to Aβ dimers and neutralise their activity are ongoing.

Explore further: 'Trigger' for stress processes discovered in the brain

More information: The presence of sodium dodecyl sulphate-stable Ab dimers is strongly associated with Alzheimer-type dementia. Jessica M. Mc Donald, George M. Savva, Carol Brayne, Alfred T. Welzel, Gill Forster, Ganesh M. Shankar, Dennis J. Selkoe, Paul G. Ince and Dominic M. Walsh on behalf of the Medical Research Council Cognitive Function and Ageing Study. Brain 2010: 133; 1328-1341

Provided by University College Dublin

5 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Recommended for you

'Trigger' for stress processes discovered in the brain

9 hours ago

At the Center for Brain Research at the MedUni Vienna an important factor for stress has been identified in collaboration with the Karolinska Institutet in Stockholm (Sweden). This is the protein secretagogin ...

New research supporting stroke rehabilitation

Nov 26, 2014

Using world-leading research methods, the team of Dr David Wright and Prof Paul Holmes, working with Dr Jacqueline Williams from the Victoria University in Melbourne, studied activity in an area of the brain ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.