Protecting nerve cells from death in a model of stroke

Sep 01, 2010

A team of researchers, led by Yizheng Wang, at the Chinese Academy of Sciences, China, has identified a way to preserve nerve cells in a rat model of stroke.

Stroke is most commonly caused by impaired delivery of oxygen to part of the brain as a result of disruption to the blood supply (a condition known as ischemia).

This leads to nerve cell death, although the exact mechanisms underlying ischemic nerve cell death have not been clearly determined.

Yang and colleagues, set out to test in rats the idea that disruption to pathways involved in protecting from death contributes to nerve cell death in and generated data consistent with this idea.

Specifically, they found that degradation of the TRPC6 preceded nerve cell death in the rat model of stroke and that suppressing TRPC6 degradation prevented nerve cell death and subsequent brain damage.

The authors therefore suggest that preventing TRPC6 degradation could be a way to limit nerve cell death after stroke.

Explore further: Fragile X study offers hope of new autism treatment

More information: View this article at: www.jci.org/articles/view/4316… da4fd780e07be0ce5d1d

Provided by Journal of Clinical Investigation

not rated yet
add to favorites email to friend print save as pdf

Related Stories

New research shows neuroprotective effect of lovastatin

Apr 09, 2008

High cholesterol levels are considered to be a risk factor for cardiovascular disease including stroke. Therefore, many cholesterol lowering drugs have been developed by pharmaceutical companies in recent years. One class ...

Calcium is spark of life, kiss of death for nerve cells

Mar 01, 2007

Oregon Health & Science University research shows how calcium regulates the recharging of high-frequency auditory nerve cells after they've fired a burst of signals, and it may have implications for neurological disorders.

Recommended for you

Stroke damage mechanism identified

8 hours ago

Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims—and are now searching for drugs to block it.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.