Free statins with fast food could neutralize heart risk, scientists say

Aug 12, 2010

Fast food outlets could provide statin drugs free of charge so that customers can neutralise the heart disease dangers of fatty food, researchers at Imperial College London suggest in a new study published this week.

Statins reduce the amount of unhealthy "LDL" cholesterol in the blood. A wealth of trial data has proven them to be highly effective at lowering a person's risk.

In a paper published in the Sunday 15 August issue of the American Journal of Cardiology, Dr Darrel Francis and colleagues calculate that the reduction in cardiovascular risk offered by a statin is enough to offset the increase in heart attack risk from eating a cheeseburger and a milkshake.

Dr Francis, from the National Heart and Lung Institute at Imperial College London, who is the senior author of the study, said: "Statins don't cut out all of the unhealthy effects of burgers and fries. It's better to avoid fatty food altogether. But we've worked out that in terms of your likelihood of having a heart attack, taking a statin can reduce your risk to more or less the same degree as a meal increases it."

One statin, simvastatin, is already available in low doses (10mg) over the counter at pharmacies without a prescription. Other statins are so far only prescribed by doctors, and limited by cost to patients at particular risk of heart attack or stroke. However, the cost of the tablets has fallen sharply in recent years (from ~£40/month to ~£1.50/month), such that the cost to the NHS of seeing a doctor is much greater than the cost of the tablet.

"It's ironic that people are free to take as many unhealthy condiments in fast as they like, but statins, which are beneficial to heart health, have to be prescribed," Dr Francis said.

Statins have among the best safety profiles of any medication. A very small proportion of regular statin users experience significant side effects, with problems in the liver and kidneys reported in between 1 in 1,000 and 1 in 10,000 people.

"Everybody knows that fast food is bad for you, but people continue to eat it because it tastes good. We're genetically programmed to prefer high-calorie foods, and sadly fast food chains will continue to sell unhealthy foods because it earns them a living.

"It makes sense to make risk-reducing supplements available just as easily as the unhealthy condiments that are provided free of charge. It would cost less than 5p per customer - not much different to a sachet of ketchup.

"When people engage in risky behaviours like driving or smoking, they're encouraged to take measures that minimise their risk, like wearing a seatbelt or choosing cigarettes with filters. Taking a statin is a rational way of lowering some of the risks of eating a fatty meal."

Studies have shown a clear link between total fat intake and blood cholesterol, which is strongly linked to heart disease. Recent evidence suggests that trans fats, which are found in high levels in fast food, are the component of the Western diet that is most dangerous in terms of heart disease risk.

Dr Francis and his colleagues used data from a previous large cohort study to quantify how a person's heart attack risk increases with their daily intake of total fat and trans fat. He compared this with the decrease in risk from various statins, based on a meta-analysis of seven randomised controlled trials.

The results showed that most statin regimes are able to compensate for the relative risk increase from eating a cheeseburger and a small milkshake.

The researchers note that studies should be conducted to assess the potential risks of allowing people to take statins freely, without medical supervision. They suggest that a warning on the packet should emphasise that no tablet can substitute for a healthy diet, and advise people to consult their doctor for more advice.

Explore further: Manipulating key protein in the brain holds potential against obesity and diabetes

More information: E.A. Ferenczi et al. "Can a statin neutralise the cardiovascular risk of unhealthy dietary choices?" American Journal of Cardiology, 15 August 2010

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Yevgen
5 / 5 (2) Aug 12, 2010
Statins have questionable benefits for wide population
that did not suffer heart attack, since some of the
studies that was supporting this "preventive" use are discredited or inconclusive:
http://www.physor...405.html
At the other hand, while acute side effects are indeed
few, long term side effect studies are starting to
emmerge and they are troubling. For example statins
are shown to cause preferential differentiation of
nerve stem cells in the brain into star cells.
What effect will this have on cognition - unknown.
It is well possible that we will observe an epidemic of some unknown disease caused by wide-range use of stains as it just recently happened with post-menopausal hormones causing breast cancer.
Based on above concerns, it is just absurd to offer
counteracting one dangerous (and easily correctable for
free) habit with another also potentially dangerous and expensive activity.

Regards,
Yevgen
JimB135
5 / 5 (4) Aug 12, 2010
Is it just me or does it seem the height of insanity to give up on trying to improve our diets and instead just serve statins along with the crap?
JimB135
not rated yet Aug 12, 2010
On second thought maybe some studies should be done to determine if we could just mix the statins into the animal feeds and make the meat more heart friendly in the first place.
Caliban
not rated yet Aug 12, 2010
Think of the money to be made!!!
With absolutely no curb on the amount of fat you can consume, why, you'd never have to cook a nasty-tasting, fresh, healthful meal again!!!! Shoot -the fast-food industry could just start manufacturing the statins side-by-side with the nutritionless breads, hormone- and antibiotic-laced meat, and chemically enhanced condiments and beverages!
Better invest in stocks now, while it's still a groundfloor opportunity...
Xaero
1.8 / 5 (5) Aug 12, 2010
Statins are rather toxic to kidney and liver and they require rather careful dosage to balance their pros & cons. Therefore they're not suitable as a common food supplement, despite their relative cheapness.
ironjustice
5 / 5 (1) Aug 13, 2010
What we SHOULD be doing is FORCING the government to FORCE these companies to include vegetable lecithin / plant oils as a REPLACEMENT for some of this fat found in our foods. THAT way we can be MUCH healthier.

"In older people, if sufficient lecithin was present in the blood, the
blood fat level returned to normal in about three hours after a high fat
meal. But, if there wasn't sufficient lecithin in the blood, fat and
cholesterol levels remained high for as long as twenty hours."