Raltegravir intensification has no effect on residual viremia in HIV-infected patients on ART

Aug 11, 2010

In a double blind trial published this week in PLoS Medicine Rajesh Gandhi and colleagues detect no significant reduction in viral load after people with low-level HIV viremia had an integrase inhibitor added to their treatment regimen.

Antiretroviral therapy (ART) consists of combinations of drugs that prevent by inhibiting essential viral enzymes such as reverse transcriptase and protease. However, despite ART, residual viremia (virus in the blood) still occurs in HIV-positive individuals. The origin of this low-level residual viremia, and whether intensification of treatment can affect it, is controversial.

In this randomized, controlled trial the researchers assessed whether the addition of raltegravir (a drug that inhibits integrase) to standard ART had any effect on residual viremia. The researchers found that the addition of raltegravir to ART for 12 weeks did not demonstrably reduce low-level residual viremia in HIV-positive individuals receiving standard ART. These findings suggest that residual viremia might be due to the release of HIV from stable reservoirs. If so, new therapeutic strategies designed to eliminate these reservoirs of latently infected cells will be required to cure HIV infection.

Explore further: Cell-associated HIV mucosal transmission: The neglected pathway

More information: Gandhi RT, Zheng L, Bosch RJ, Chan ES, Margolis DM, et al. (2010) The Effect of Raltegravir Intensification on Low-level Residual Viremiain HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial. PLoS Med 7 (8): e1000321. doi:10.1371/journal.pmed.1000321

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Cambodia orders probe into mass HIV infection

Dec 18, 2014

Cambodian Prime Minister Hun Sen on Thursday ordered a probe into an apparent mass HIV infection believed to have been spread by contaminated needles, as the number of suspected cases passed 100.

A fresh setback for efforts to cure HIV infection

Dec 17, 2014

Researchers are reporting another disappointment for efforts to cure infection with the AIDS virus. Six patients given blood-cell transplants similar to one that cured a man known as "the Berlin patient" have ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.