New perspectives on local calcium signaling

Jul 26, 2010
A schematic model for the local control of EC coupling and ET coupling in nerve and muscle is part of the Perspectives on Local Calcium Signaling in the August issue of the Journal of General Physiology. Credit: Santana, L.F., and M.F. Navedo. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910391.

The latest Perspectives in General Physiology series introduces the newest technologies in the field of calcium signaling, which plays a central role in many cellular processes. The Perspectives appear in the August issue of the Journal of General Physiology.

A revolution in measuring Ca2+ signals has taken place over the last decade, benefiting from advances in microscopy, buffers/dyes, and other technologies. This means researchers now have the tools to answer questions about how fast signals initiate, what terminates them, how quickly they terminate, how far they spread, how many channels it takes to kick off a signaling event, and many other questions that classical techniques simply couldn't answer. In addition to introducing the new tools, the authors apply these technologies to muscle and nerve cell Ca2+ channel.

The Perspectives are introduced by their organizer, Sharona Gordon (University of Washington), and include contributions from Mark Nelson (University of Vermont, University of Manchester) and colleagues; Ian Parker and Ian Smith (University of California, Irvine); W.J. Lederer (University of Maryland) and colleagues; Luis Santana and Manuel Navedo (University of Washington); and Heping Cheng (Peking University) and colleagues.

The purpose of the Perspectives in General Physiology series is to provide an ongoing forum where scientific questions or controversies can be discussed by experts in an open manner.

Explore further: Computer models help cerebral palsy patients step out

More information:
Gordon, S.E. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010491
Hill-Eubanks, D.C., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010402
Parker, I., and I.F. Smith. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910390
Prosser, B.L., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010406
Santana, L.F., and M.F. Navedo. 2010. J. Gen. Physiol. doi:10.1085/jgp.200910391
Xie, W., et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010416

add to favorites email to friend print save as pdf

Related Stories

Studies shed new light on early transmembrane signaling

Jan 25, 2010

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular ...

Mechanism explains calcium abnormalities in Alzheimer's brain

Jun 25, 2008

A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease (AD) with aberrant calcium signaling. The research, published by Cell Press in the June 26th issue of the journal Neuron, provid ...

Unraveling the mysteries of poison

Apr 13, 2006

Researchers from the Max Planck Institite for Biophysical Chemistry and other German and French colleagues have combined magnetic resonance spectroscopy (solid-state NMR) with special protein synthesis procedures to uncover ...

Recommended for you

Scientists discover gene controlling muscle fate

20 hours ago

Scientists at the University of New Mexico have moved a step closer to improving medical science through research involving muscle manipulation of fruit flies. They discovered in the flight muscles of Drosophila ...

Study clues to aging bone loss

20 hours ago

In Canada, bone fractures due to osteoporosis affect one in three women and one in five men over their lifetimes, costing the health care system more than $2.3 billion a year.

User comments : 0