Minor kidney damage in people with type 1 diabetes leads to increased mortality

Jun 27, 2010

People with type 1 diabetes who have early and asymptomatic kidney damage, as indicated by small amounts of protein in the urine, are six times more likely to die compared to the general population, say researchers at the University of Pittsburgh Graduate School of Public Health. Their study, being presented at the 70th Scientific Sessions of the American Diabetes Association, also found that when kidneys remained normal over time, people with type 1 diabetes had no greater risk of death than their healthy counterparts.

The findings, abstract number 0917-P, were based on data from 658 men and women enrolled in the Pittsburgh Epidemiology of Diabetes Complications Study, a long-term prospective examination of childhood onset type 1 diabetes that began in 1986. Researchers tested participants for levels of albumin, a protein that indicates early kidney damage when elevated in the urine and results in a condition called microalbuminuria.

After 20 years of follow-up, 152 participants (23 percent) with microalbuminuria had died - a rate 6.2 times higher than age- and sex-matched people in the general population. When researchers excluded from the analysis participants who developed after initial protein testing, they found that for those with normal kidneys were no different than in the general population.

"Early stages of kidney disease in type 1 may be very important because they can lead to a sizeable increase in the risk of death," said Aaron M. Secrest, lead author of the study and a doctoral student at the University of Pittsburgh Graduate School of Public Health. "The hopeful news is that this risk virtually disappears when kidneys remain healthy, which should encourage physicians to closely monitor kidney health in people with ."

Explore further: Liberia holds Senate vote amid Ebola fears

add to favorites email to friend print save as pdf

Related Stories

No heart benefit from Omega-3 in women with type 1 diabetes

Jun 27, 2010

Consuming higher amounts of omega-3 fatty acids does not appear to lower heart disease risk for women with type 1 diabetes, according to a University of Pittsburgh Graduate School of Public Health study being presented at ...

Weight gain may be healthy when it comes to type 1 diabetes

Jun 07, 2008

Gaining body fat may be a good thing, at least for people with type 1 diabetes, say researchers at the University of Pittsburgh Graduate School of Public Health. Their study, being presented at the 68th Scientific Sessions ...

Can too much HDL be harmful to women with type 1 diabetes?

Jun 27, 2010

Elevated blood levels of high-density lipoprotein (HDL) or "good" cholesterol, typically thought to protect against heart disease, may do the opposite in women with type 1 diabetes, according to a University of Pittsburgh ...

'Silent strokes' linked to kidney failure in diabetics

Jan 28, 2010

In patients with type 2 diabetes, silent cerebral infarction (SCI) -- small areas of brain damage caused by injury to small blood vessels -- signals an increased risk of progressive kidney disease and kidney failure, according ...

Recommended for you

Liberia holds Senate vote amid Ebola fears

46 minutes ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate vote that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

20 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

21 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

21 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

Dec 19, 2014

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.