What affects the gastrointestinal symptoms in peritoneal dialysis patients?

Jun 24, 2010

Gastrointestinal symptoms are common in peritoneal dialysis patients. A research group in China investigated the gastrointestinal symptoms in peritoneal dialysis patients and explored the related factors. Eating dysfunction, reflux and indigestion were the most common gastrointestinal complaints. Patient with a history of corticosteroid therapy or taking more pills daily was more likely to develop gastrointestinal symptoms, while the better the residual renal function, the less likely the patient was to have these symptoms.

Gastrointestinal (GI ) symptoms are proven to be more common in patients undergoing peritoneal dialysis than in patients with chronic renal failure having hemodialysis. However, whether the onset of these GI symptoms is related to the chronic renal failure itself, its treatment, or alternatively, other factors, is still unknown.

A research article to be published on June 14, 2010 n the addresses this question. The research team led by Professor Guo from the Nephrology department of Changhai Hospital, Second Military Medical University used the Gastrointestinal Symptom Rating Scale, which is a self-administered questionnaire, includes 15 items and uses a 7-grade Likert scale defined by descriptive anchors such that 1=none, 2=minor, 3=mild, 4=moderate, 5=moderately severe, 6=severe, and 7=very severe discomfort, to evaluate the presence of in peritoneal dialysis patients. As various research groups have indicated a higher prevalence of gastrointestinal symptoms in patients undergoing peritoneal dialysis than in patients with chronic renal failure having hemodialysis, the article further investigates the possible correlated factors affecting the gastrointestinal symptoms in peritoneal dialysis patients by using multiple regression analysis.

The prevalence of eating dysfunction, reflux and indigestion in peritoneal dialysis patients was 44.2%, 32.7%, 32.7%, respectively. A history of corticosteroid therapy and the number of all pills the patients took daily were positively correlated to GI symptoms, while residual renal Kt/V was negatively correlated to GI symptoms.

These findings indicated that gastrointestinal symptoms in peritoneal dialysis patients were more correlated with chronic renal failure itself and other treatment-associated factors, but not with peritoneal dialysis-associated factors. Residual is not only an index regarding the uremia itself but an index predicting complications. Iatrogenic factors were another aspect impacting the gastrointestinal symptoms in peritoneal dialysis patients, including the pre-dialytic therapy and adjuvant therapy during peritoneal dialysis.

Explore further: Study shows Tamiflu gets patients back on their feet faster, reduces flu complications

More information: Dong R, Guo ZY. Gastrointestinal symptoms in patients undergoing peritoneal dialysis: Multivariate analysis of correlated factors. World J Gastroenterol 2010; 16(22): 2812-2817 www.wjgnet.com/1007-9327/full/v16/i22/2812.htm

add to favorites email to friend print save as pdf

Related Stories

New peritoneal dialysis diagnostic discovered

Oct 17, 2007

Thanks to a discovery by scientists at Robarts Research Institute and The University of Western Ontario, patients undergoing peritoneal dialysis may soon be able to worry less about the risks of infection and lessen their ...

Diabetic factors associated with gastrointestinal symptoms

Apr 12, 2010

There are several papers which report the association of GI symptoms with diabetes. Epidemiological data regarding the association of GI symptoms with diabetes are, however, inconsistent, and the reported frequency of upper ...

Dialysis safe for kidney patients' heart health

Jul 09, 2009

Dialysis treatments do not affect the heart health of kidney disease patients who have had a heart attack, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN ...

Recommended for you

Kidney-brain connection may help drive chronic kidney disease

14 hours ago

In addition to affecting blood pressure, high-salt intake can promote kidney function decline in patients with chronic kidney disease. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (J ...

Flu's grip on U.S. starting to weaken: CDC

14 hours ago

(HealthDay)—After a rough start to the flu season, the number of infections seems to have peaked and is even starting to decline in many parts of the nation, federal health officials reported Thursday.

Litchi fruit suspected in mystery illness in India

14 hours ago

A mysterious and sometimes fatal brain disease that has afflicted children in northeastern India for years could be linked to a toxic substance in litchi fruits, US researchers said Thursday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.