Bariatric surgery in diabetic adults improves insulin sensitivity better than diet

Jun 21, 2010

Gastric bypass surgery improves Type 2 diabetes by other mechanisms in addition to weight loss and does so better than a low-calorie diet despite achieving equal weight loss, a new study finds. The results will be presented Monday at The Endocrine Society's 92nd Annual Meeting in San Diego.

"Our study shows that in the short term, by alone does not achieve the same improvements in diabetes as gastric bypass surgery," said the presenting author, Judith Korner, MD, PhD, assistant professor of medicine at Columbia University College of Physicians and Surgeons, New York.

Korner and her colleagues found that gastric bypass surgery better improved insulin sensitivity, the body's ability to successfully clear glucose sugar from the bloodstream into the cells. Insulin sensitivity is impaired in people with Type 2 diabetes, and obesity adds to this problem. The result is a buildup of sugar in the blood.

The study compared the effects on diabetic adults of a low-calorie diet versus Roux-en-Y gastric bypass, the most common gastric bypass procedure. Roux-en-Y gastric bypass decreases the size of the stomach and reroutes the digestive tract to bypass most of the stomach and part of the small intestine. After gastric bypass, many diabetic patients achieve normal blood glucose control or vastly improved control, and some may no longer require diabetes medications.

In the study, seven obese patients with Type 2 diabetes received a daily 800-calorie liquid diet and no surgery, while seven other obese diabetic adults underwent . The study ended when both groups lost the same amount of weight: an average of 8 percent of body weight. However, the surgery-treated patients lost the weight faster: in about 3.5 weeks compared with 8 weeks for the dieters.

Surgical patients were able to discontinue all of their diabetes medications by the study's end, but the dieters reduced their medication use by 55 percent, Korner reported.

The researchers found significant improvements in the surgery group in measures of insulin sensitivity and function of beta cells, the insulin-producing cells in the pancreas. Improvements in in the low-calorie diet group was not statistically significant and beta cell function improved to a lesser extent.

Korner speculated that hormonal changes may be responsible for the improvements resulting from Roux-en-Y surgery in individuals with .

"It will be important to understand how surgery works to produce these results so that we can develop medical therapies of equivalent efficacy," she said.

Explore further: Obama's Ebola response: Is it enough and in time?

add to favorites email to friend print save as pdf

Related Stories

Be Aware of Blood Sugar Post Gastric Bypass

Jan 04, 2010

(PhysOrg.com) -- People with type 2 diabetes who have gastric bypass surgery often leave the hospital without the need for previously prescribed diabetes medications.

How gastric bypass rapidly reverses diabetes symptoms

Sep 02, 2008

A report in the September Cell Metabolism, a publication of Cell Press, offers new evidence to explain why those who undergo gastric bypass surgery often show greater control of their diabetes symptoms within days. It als ...

Study Puts Bariatric Surgery for Type 2 Diabetes to the Test

Dec 29, 2009

(PhysOrg.com) -- A multi-disciplinary team of Penn researchers, including diabetes, weight loss and bariatric surgery experts, are conducting a study funded by the National Institutes of Health (NIH) to determine if bariatric ...

Why can surgical treatment improve type 2 diabetes mellitus?

May 12, 2010

Roux-en-Y gastric bypass (RYGB) is a commonly used surgical treatment for patients with morbid obesity. It significantly and persistently decreases the levels of blood glucose and glycosylated hemoglobin in 80-100 percent ...

Recommended for you

Obama's Ebola response: Is it enough and in time?

1 hour ago

President Barack Obama declared Tuesday that the Ebola epidemic in West Africa could threaten security around the world, and he ordered 3,000 U.S. military personnel to the region in emergency aid muscle ...

First domestic case of chikungunya in Brazil

1 hour ago

Brazil's authorities on Tuesday reported the first domestically contracted cases of the mosquito-borne chikungunya virus, prompting the government to announce it was stepping up attempts to control the disease.

Australia promises $6.4 million to fight Ebola

1 hour ago

Australia announced on Wednesday it will immediately provide an additional 7 million Australian dollars ($6.4 million) to help the international response to the Ebola outbreak in West Africa.

Tracing the rise of Ebola in West Africa

11 hours ago

Since the Ebola outbreak first emerged in West Africa, The Associated Press has been reporting on it. A timeline compiled from AP dispatches since March shows the dreaded disease being identified in a remote ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

CutTheCarb
not rated yet Jun 22, 2010
Don't think they took the right diet to compare the diet with. Obesity and the often following diabetes can easily and much more save be cured by a low carb and hig fat diet; Watch
http://bit.ly/duSiUK VBR