Therapeutic potential of embryonic stem cells

Jun 18, 2010

Are stem cells ready for prime time? The therapeutic potential of embryonic stem cells has been an intense focus of study and discussion in biomedical research and has resulted in technologies to produce human induced pluripotent stem cells (hiPSCs). Derived by epigenetic reprogramming of human fibroblasts, these hiPSCs are thought to be almost identical to human embryonic stem cells (hESCs) and provide great promise for patient-tailored regenerative medicine therapies. However, recent studies have suggested noteworthy differences between these two stem cell types which require additional comparative analyses.

Scientists at Children's Memorial Research Center at Northwestern University Feinberg School of Medicine investigated the expression of key members of the Nodal embryonic signaling pathway, critical to maintaining , in hiPSC and hESC cell lines. Nodal is an important - a soluble molecule that can regulate cell fate - in embryological systems that requires tight regulatory control of its .

The group's results demonstrated slightly lower levels of Nodal and Cripto-1 (Nodal's co-receptor) and a dramatic decrease in Lefty (Nodal's inhibitory regulator) in hiPSCs compared with hESCs, suggesting less regulatory control of cell fate in reprogrammed stem cells. Based on these findings, additional work addressed the implications associated with the epigenetic reprogramming of hiPSCs and examined a global comparative analysis of 365 microRNAs (miRs) in hiPSC vs. hESC lines.

The data revealed 10 highly expressed miRs in hiPSCs with greater than 10-fold difference, which have been shown to be cancer related. Collectively, these data demonstrate cancer hallmarks expressed by hiPSCs, which will require further elucidation for their impact on clinical applications, especially with respect to the fate of precancerous stem cells.

Explore further: Do men's and women's hearts burn fuel differently?

More information: Entitled "Cancer hallmarks in induced pluripotent cells: new insights", this paper is published online in the Journal of Cellular Physiology.

Provided by Children's Memorial Hospital

not rated yet
add to favorites email to friend print save as pdf

Related Stories

What makes stem cells tick?

Aug 06, 2009

Investigators at the Burnham Institute for Medical Research (Burnham) and The Scripps Research Institute (TSRI) have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells (hESCs) ...

Protein is key to embryonic stem cell differentiation

Mar 18, 2009

Investigators at Burnham Institute for Medical Research (Burnham) have learned that a protein called Shp2 plays a critical role in the pathways that control decisions for differentiation or self-renewal in both human embryonic ...

Recommended for you

Common food supplement fights degenerative brain disorders

2 hours ago

Widely available in pharmacies and health stores, phosphatidylserine is a natural food supplement produced from beef, oysters, and soy. Proven to improve cognition and slow memory loss, it's a popular treatment for older ...

Finding a family for a pair of orphan receptors in the brain

2 hours ago

Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...

Insight into the dazzling impact of insulin in cells

3 hours ago

Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.

Do men's and women's hearts burn fuel differently?

6 hours ago

Researchers at the University of Illinois at Chicago College of Medicine will study gender differences in how the heart uses and stores fat—its main energy source—and how changes in fat metabolism play ...

Study suggests new source of kidneys for transplant

22 hours ago

Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too ...

User comments : 0

More news stories

B vitamins could delay dementia

(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...

Internet cable from Cuba to Jamaica comes online

A new branch of the Venezuela-to-Cuba undersea fiber-optic cable has reportedly come online, linking the island to nearby Jamaica, increasing Cuba's potential international communications bandwidth and providing a backup ...