Blueberry ameliorates hepatic fibrosis

Jun 17, 2010

A research team from China examined the effect of blueberry on hepatic fibrosis and detoxification enzyme systems in rats. The results demonstrated that blueberry has a therapeutic effect on CCl4-induced hepatic fibrosis by reducing hepatocyte injury and lipid peroxidation.

Conventional drugs used in the treatment of liver diseases inevitably have side effects. An increasing number of natural substances have been studied to explore if they have protective effects on the liver. Blueberries have unique effects on human retinal, brain and tumor cells, but reports about the effects of blueberries on liver diseases are lacking.

A research article to be published on June 7, 2010 in the addresses this question. The research team led by Ming-Liang Cheng, MD, from Department of Infectious Diseases, Guiyang Medical College, Guiyang, presented some data from their research on the effectiveness of on liver fibrosis induced in laboratory animals.

Their study showed that blueberries could reduce liver indices, serum levels of hyaluronic acid and alanine aminotransferase, and increase levels of superoxide dismutase and decrease levels of malondialdehyde in liver homogenates compared with the model group. Meanwhile, the stage of hepatic fibrosis was significantly weakened. Blueberries increased the activity of glutathione-S-transferase in liver homogenates and the expression of Nrf2 and Nqo1 compared with the normal group, but there was no significant difference compared with the model group.

The authors suggest that blueberry consumption is beneficial for hepatic diseases (including fibrosis).

Explore further: WHO: 700 more Ebola cases emerge in only one week

More information: Wang YP, Cheng ML, Zhang BF, Mu M, Wu J. Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroenterol 2010; 16(21): 2657-2663 www.wjgnet.com/1007-9327/full/v16/i21/2657.htm

add to favorites email to friend print save as pdf

Related Stories

Antifibrotic effects of green tea

Nov 18, 2009

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects ...

How does emodin protect rat liver from fibrogenesis?

Oct 23, 2009

In the last decade, advances in the understanding of genes promoting hepatic stellate cell (HSC) activation are impressive. However, there are few breakthroughs in therapeutic intervention of hepatic fibrogenesis. Efficient ...

How did glycine significantly decrease liver injury?

Oct 31, 2008

The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin ...

Recommended for you

Swatting chikungunya

2 hours ago

Summer days may be waning, but health officials are still on high alert for new cases of chikungunya, a painful mosquito-borne virus that spread to the United States from the tropics earlier this year. ...

Sierra Leone readies for controversial Ebola lockdown

2 hours ago

Sierra Leone prepared Thursday for an unprecedented three-day nationwide lockdown to contain the deadly spread of the Ebola virus in a controversial move which experts claimed could worsen the epidemic.

Nepal adopts jab to boost polio fight

2 hours ago

Nepal on Thursday launched a drive to eradicate polio by supplementing oral vaccines with an injection that experts say will boost children's immunity against the disease.

User comments : 0