Down's Syndrome Chromosome Yields More Cancer-Blocking Genes

Jun 11, 2010

(PhysOrg.com) -- Scientists from Queen Mary, University of London have discovered cancer-blocking activity for genes carried on chromosome 21 - an extra copy of which is carried by people with Down’s syndrome.

The study, published in Nature, investigated why the extra copy of chromosome 21 provides protection against the development of solid cancers.

The team found that tumour growth was reduced significantly in mice with three copies of genes from chromosome 21, compared with mice carrying two copies - the extra set of these genes boosting protection against development.

They identified that a number of genes called ADAMTS1; ERG; JAM-B and PTTG11P can block the formation of blood vessels to tumours - a process called angiogenesis. This prevents nutrients reaching the tumour, in effect ‘starving it,’ stopping the cancer from growing. Two of these genes JAM-B and PTTG11P were previously unlinked to angiogenesis.

The discovery that these new genes block a protein called vascular endothelial growth factor (VEGF), which triggers new blood vessel growth, presents new targets for research into potential .

Lead author, Kairbaan Hodivala-Dilke, Professor of Angiogenesis at Barts and The London School of Medicine and Dentistry’s Institute of Cancer, part of Queen Mary, University of London, said: "These exciting results provide new evidence to confirm that having three copies of certain genes on chromosome 21 is sufficient to protect against tumour growth.

“The next stage is to think about how we might be able to exploit this and use it to develop cancer treatments in the future to block tumour growth."

Professor Kairbaan Hodivala-Dilke and her team have been studying why people with Down’s syndrome have a lower risk of developing some types of cancer for a number of years.

She added: “It’s incredibly inspiring to know that by studying the genetic make-up of people with Down’s syndrome we have been able to make important discoveries that help us understand far more about the intricate processes involved in cancer tumour growth.”

Dr Lesley Walker, director of cancer information at Cancer Research UK said: “Investigating potential drugs that ‘starve’ tumours of their blood supply is an exciting area of research and one that we are investing heavily in.

“The exciting discovery that more have been located on which are natural cancer protectors opens up a new store of gene therapy opportunities to beat the disease.”

Explore further: Disease decoded: Gene mutation may lead to development of new cancer drugs

More information: Tumour angiogenesis is reduced in the Tc1 mouse model of Down syndrome. Reynolds et al. Nature.

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User comments : 12

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freethinking
1 / 5 (2) Jun 11, 2010
I find it amazing. There are many people (mostly progressives) who would like nothing better than see all Down syndrome kids identified and killed before they are born.

Wouldn't it be ironic if the cure to cancer is found in them.
MarkyMark
not rated yet Jun 12, 2010
I find it amazing. There are many people (mostly progressives) who would like nothing better than see all Down syndrome kids identified and killed before they are born.

Wouldn't it be ironic if the cure to cancer is found in them.


I agree we could even setup Down-Farms to harvest this new wonderdrug.

Joking of course but seriously are there people that want to exterminate them all!!!
freethinking
1 / 5 (1) Jun 12, 2010
Dont get me wrong MarkyMark, I am all in favor of curing or preventing downs if that were possible.

Actually, if you are shown to have a downs baby, there is a lot of pressure by the medical community to kill the baby. Also Planned Parenthood, and a lot of other progressives deem Downs people to be less than human, a drain on resources, and have a lower quality of life.
otto1923
5 / 5 (1) Jun 12, 2010
You're an idiot. Does that mean you need to be killed? Absolutely not. Only ... corrected.

Downs is a disease and the people who have it would be much better off if they didn't. Just to be OT.
freethinking
Jun 13, 2010
This comment has been removed by a moderator.
Skeptic_Heretic
not rated yet Jun 14, 2010
I find it amazing. There are many people (mostly progressives) who would like nothing better than see all Down syndrome kids identified and killed before they are born.

Wouldn't it be ironic if the cure to cancer is found in them.

WTF are you smoking? We want to cure it, not kill the carriers.

Killing people who are different from the social norm is the hallmark of religion, not progressivism.
freethinking
1 / 5 (1) Jun 14, 2010
sorry SH, you are wrong again. Killing people who are different from the social norm is a hallmark of progressivism.

Please see lookup what the founder of Planned Parenthood believed. Then there are the Nazi's and communists. You need to do a bit of research.
Skeptic_Heretic
1 / 5 (1) Jun 14, 2010
sorry SH, you are wrong again. Killing people who are different from the social norm is a hallmark of progressivism.
Assertion from a subjective viewpoint doesn't create truth outside of dogma.
Please see lookup what the founder of Planned Parenthood believed.
Margaret Sanger was a lunatic, everyone agrees on that.
Then there are the Nazi's
Devout Christians who killed the Jews because they were an easy scapegoat due to closed society and different customs and traditions.
and communists.
Would that be why the eastern orthodox church cranks out Stalin gear for it's worshippers?
You need to do a bit of research.

Right back at ya.
freethinking
1 / 5 (1) Jun 14, 2010
Glad you think Margaret Sanger was a lunatic, so I hope you'll agree that her organization planned parenthood is crazy as well.

Devout Christians killed Jews. Well please define a devout Christian. Is it one who follows the bible, or who follows the crowd? What part of Thou Shalt Not Kill, and Love they Neighbor, turn the other cheek did they miss?

Eastern Orthodox churches corrupted by communists? Sure. When the state and progressives control the churches what do you expect. Soon, if thing continue here as they are, preachers will need to have their sermons approved here as they did there.

Again your ignornace of history, and Christianity is astounding. You need to dig deeper and ask the question why instead of accepecting what you were told by a progressive teacher, book, or TV show.

You have a sterotype of Christians that is demonstratively false, however no amount of evidence will sway you. Like I told you in the past, convince a skeptic and nothing will sway them.
Skeptic_Heretic
1 / 5 (1) Jun 15, 2010
Devout Christians killed Jews. Well please define a devout Christian. Is it one who follows the bible, or who follows the crowd? What part of Thou Shalt Not Kill, and Love they Neighbor, turn the other cheek did they miss?
Those same tenets haven't stopped Christians from waging war for the better part of 1500 years or more now.
Eastern Orthodox churches corrupted by communists? Sure. When the state and progressives control the churches what do you expect.
Right, it's corruption of a holy church by evil progressives, or maybe the church is just evil.
Again your ignornace of history, and Christianity is astounding. You need to dig deeper and ask the question why instead of accepecting what you were told by a progressive teacher, book, or TV show.

This is hilarious, let me show you why.
You need to dig deeper and ask the question why instead of accepting what you were told by a preacher, book, or TV evangelist.
freethinking
1 / 5 (1) Jun 15, 2010
SH, now misquoting me and changing my words.... nice.
Ok, how about you count the number of times you asked deeper questions about anit-christian statements made by progressives, and I count the number of times I questioned tv preachers, books, etc. (FYI, I've been in the paper a long time ago questioning motives of certain preachers.) I've said it may times, Prove all things, Hold fast to that which is true.
You hate Christians, so you will never question anything you believe proves christians are stupid or hateful.
So I ask you what obviously false statement about christians have you ever questioned?
MichaelExe
not rated yet Jun 19, 2010
WTF are you smoking? We want to cure it, not kill the carriers.

Killing people who are different from the social norm is the hallmark of religion, not progressivism.


Abortion. Are you supporting the "potential of sentience"? Even ovums and spermatozoa possess it. You can't make use of every one.
Religion gave westerners a sense of righteousness and of superiority over the natives, but it didn't give them the right to kill them. If they were religious, they were doing it wrong. The same goes for Christian Nazis and the Jews. Suicide is even one of the worst sins in Islam.

Now, religion doesn't really serve a purpose, but catholicism might have been one of the greatest contraceptives in the history of mankind. No sex before marriage keeps us from making a kid we're not ready for, but no one's really ready to raise a kid with Down's syndrome.

How do you expect to cure Down's syndrome? It affects every cell, so to cure it would be to alter the genes in the zygote or the gamete.
freethinking
1 / 5 (1) Jun 19, 2010
MichaelExe, I think your athiestic brain needs a basic science lesson. Ovums and spermatozoa do not grow to become humans unless combined. Seperate they are just like, or even less than skin cells.

BTW ask any parent, no one is ready to raise any kid.