Molecular imaging agent coupled with 'motion frozen' processing improves heart imaging

Jun 07, 2010

Molecular imaging of the heart just got better, according to a study revealed at SNM's 57th Annual Meeting. Combining a potential new imaging agent with a molecular imaging technique that reduces blur caused by the motion of the heart and lungs could lead to unprecedented image quality when conducting myocardial perfusion imaging, a procedure used to evaluate blood flow to the heart.

"Both cardiac and respiratory motion degrade image quality by adding some unwanted blur," said Ludovic Le Meunier, Ph.D., lead researcher and staff scientist for Siemens Healthcare, Knoxville, Tenn., based at Cedars-Sinai Medical Center, Los Angeles, Calif. "Our objective in this work was to provide the highest myocardial perfusion image quality by using a promising heart imaging agent and correcting the motion of those organs. In conjunction, these tools can provide unprecedented diagnostic capability for clinicians evaluating heart disease."

The new imaging agent, called flurpiridaz F 18 injection, uses a fluorine-18 (F-18) based radioisotope, and while it is still in clinical trials, the compound has been shown to facilitate very high-quality imaging of the heart. Other positron (PET) agents used to image the heart have a much shorter half-life and need to be produced within an on-site , which limits access. Some agents can be produced on-site with a generator, but image quality appears not to be as high. F-18 has a half-life of 108 minutes and therefore can be delivered to imaging centers located within a wider radius, with no compromise to image quality.

The technology used in this study included high-definition, or "HD" PET, a technique that images the body's physiological functions and automatically corrects distortions that occur during scanning. Next, researchers used post-scan image processing tools called respiratory gating and "motion-frozen" cardiac gating, which cut out or otherwise compensate for the motion of these organs during scanning. The result is virtually motion-free myocardial perfusion imaging.

Explore further: Novel marker discovered for stem cells derived from human umbilical cord blood

add to favorites email to friend print save as pdf

Related Stories

Faster, more precise MRI for the medical world

Sep 25, 2004

Magnetic Resonance Imaging (MRI) revolutionised the medical world two decades ago, providing doctors with an unparalleled view inside the human body. Now, MRI-MARCB has taken MRI to a new level with a system that enhance ...

Recommended for you

New pain relief targets discovered

1 hour ago

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching ...

Building 'smart' cell-based therapies

2 hours ago

A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other ...

Proper stem cell function requires hydrogen sulfide

5 hours ago

Stem cells in bone marrow need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Herman Ostrow School of Dentistry ...

User comments : 0

More news stories

Researchers discover target for treating dengue fever

Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other ...

Study recalculates costs of combination vaccines

One of the most popular vaccine brands for children may not be the most cost-effective choice. And doctors may be overlooking some cost factors when choosing vaccines, driving the market toward what is actually a more expensive ...

Hackathon team's GoogolPlex gives Siri extra powers

(Phys.org) —Four freshmen at the University of Pennsylvania have taken Apple's personal assistant Siri to behave as a graduate-level executive assistant which, when asked, is capable of adjusting the temperature ...

Better thermal-imaging lens from waste sulfur

Sulfur left over from refining fossil fuels can be transformed into cheap, lightweight, plastic lenses for infrared devices, including night-vision goggles, a University of Arizona-led international team ...

Deadly human pathogen Cryptococcus fully sequenced

Within each strand of DNA lies the blueprint for building an organism, along with the keys to its evolution and survival. These genetic instructions can give valuable insight into why pathogens like Cryptococcus ne ...