Researchers discover potential genetic factor in eating disorders

Jun 04, 2010

For the first time, scientists have discovered a possible biological culprit in the development of eating disorders during puberty: a type of estrogen called estradiol.

The groundbreaking pilot study led by Michigan State University found that influence of one's on symptoms was much greater in pubertal girls with higher levels of estradiol than pubertal girls with lower levels of estradiol. The study appears in the journal .

Lead investigator Kelly Klump, MSU associate professor of psychology, said previous research had established that eating disorders are influenced by both genetic and environmental factors once a girl hits puberty.

The underlying effects of the genes, however, were unknown.

"The reason we see an increase in genetic influences during puberty is that the genes for are essentially getting switched on during that time," said Klump. "This research was trying to figure out why. What's turning on the genes during ? And what we found is that increases in estradiol apparently are activating for eating disorders."

Estradiol is the predominant form of estrogen in females and is responsible for the growth of reproductive organs and also influences other organs including bones.

Klump noted that researchers don't yet know which genes are being switched on by estradiol. Further, she said a larger study is needed to confirm the results of the MSU-led research.

But knowing that estradiol likely plays a role in the development of eating disorders could ultimately open the window to new treatments, said Klump, past president of the Academy of Eating Disorders.

In addition, she said, prevention efforts could be geared toward those girls who not only are in high-risk environmental contexts (such as weight-focused sports), but also those with genetic risks such as a family history of eating disorders.

The study examined the estradiol levels of nearly 200 sets of female twins, ages 10-15, from the MSU Twin Registry, which includes more than 5,000 pairs of twins in Michigan. Klump runs the registry with S. Alexandra Burt, assistant professor of psychology.

Explore further: Psychiatric disorder prevalence among homeless young

add to favorites email to friend print save as pdf

Related Stories

Sun-damaged skin does not improve with estrogen treatments

Sep 15, 2008

Treating the skin with estrogen can stimulate collagen production—which improves the appearance of the skin—in areas not typically exposed to the sun, according to new research from the University of Michigan Health System.

Recommended for you

A blood test for suicide?

4 hours ago

Johns Hopkins researchers say they have discovered a chemical alteration in a single human gene linked to stress reactions that, if confirmed in larger studies, could give doctors a simple blood test to reliably predict a ...

Could summer camp be the key to world peace?

19 hours ago

According to findings from a new study by University of Chicago Booth School of Business Professor Jane Risen, and Chicago Booth doctoral student Juliana Schroeder, it may at least be a start.

Gender disparities in cognition will not diminish

Jul 28, 2014

The study, published in the Proceedings of the National Academy of Science, investigated the extent to which improvements in living conditions and educational opportunities over a person's life affect cognitive abilities and th ...

User comments : 0