Novel technique informs drug delivery research

Jun 03, 2010
Novel technique informs drug delivery research

University College Dublin researchers led by Conway Fellow, Professor David Brayden have shown that a candidate drug delivery polymer may have potential for oral or topical use. These findings were recently published in the Journal of Controlled Release.

The team of scientists, who are part of the Science Foundation Ireland- funded Irish Network, set out to investigate if an antibacterial synthetic polymer called pDMAEMA [poly(2-(dimethylamino ethyl)methacrylate] is as damaging to normal human cells as it is to bacteria.

This sticky polymer binds membranes and previous research by the team demonstrated that it has a novel bactericidal action against a range of bacteria. This finding has led to pDMAEMA being proposed as a surface-coating for medical devices in an effort to reduce the number of hospital-acquired infections.

This study, which formed part of the doctoral research by lead author Lee-Anne Rawlinson, used high content analysis, a non-invasive imaging technique that can monitor a number of parameters over a time period using up to eight . It has an unique advantage over other techniques in that it does not interfere with cells during the analysis.

The findings showed that pDMAEMA was cytotoxic to , but not to intestinal epithelial , and that it did not damage intestinal mucosae in the model used even in high concentrations. This would suggest that the polymer might have potential for oral or topical use, rather than by systemic injection.

Explore further: New method to reduce the optical band gap of strontium titantate thin films

More information: High content analysis of cytotxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures. Lee-Anne B Rawlinson, Peter J. O’Brien, David J. Brayden. Journal of Controlled Release. May 7. [Epub ahead of print] PMID: 20457190.

Provided by University College Dublin

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Penicillin-coated biomaterial created

Jan 17, 2007

U.S. scientists have developed a penicillin-coated version of a polymer biomaterial to protect polymer-based surgical devices and medical implants.

Making Better Magnetic Nanoparticles

Dec 18, 2006

Using a polymer coating designed to resemble the outer surface of a cell membrane, a team of investigators led by Steve Armes, Ph.D., of the University of Sheffield in the United Kingdom, has created a highly stable, biocompatible ...

Cancer-causing gut bacteria exposed

Sep 22, 2008

Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. Now, scientists from the USA have discovered that a molecule produced by a common gut bacterium activates signalling ...

Recommended for you

A renewable bioplastic made from squid proteins

23 hours ago

In the central Northern Pacific is an area that may be the size of Texas called the Great Pacific Garbage Patch. Made up of tons of floating plastic debris, the patch is killing seabirds and poisoning marine ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.