A risk factor of gallstone formation after radical gastrectomy

Jun 02, 2010

The incidence of gallstones is higher in patients after radical gastrectomy than in the general population. The current literature suggests that this higher incidence is related to gallbladder motility disorder after surgery. A research group in China investigated the association between the XbaI polymorphisms of APOB gene and gallstone formation after gastrectomy. Patient with the X+ allele of APOB gene was found to be another important risk factor of gallstone formation after radical gastrectomy.

The cause of higher incidence of gallstone after radical gastrectomy still remains unknown. Almost all previous studies have attributed gallstone formation to gallbladder motility disorder after gastrectomy, But this theory cannot completely explain it. Is there any other risk factor of gallstone formation after gastrectomy?

A research article to be published on May 28, 2010 in the addresses this question. The research team led by Professor Niu from Zhongshan Hospital of Fudan University enrolled 206 patients between January 2005 and December 2006, who underwent radical gastrectomy for gastric cancer. These patients were grouped according to XbaI of APOB gene.

After at least 2 years follow up, they found that the incidence of gallstone following gastrectomy was significiantly higher in patients with the X+ allele of APOB gene, who have a higher concentration of TC and LDL. These results demonstrate that the X+ allele may influence the levels of TC and LDL, resulting in an increased saturation of bile cholesterol, leading to the gallstone formation after gastrectomy. The authors believe besides the motility disorder, X+ allele of APOB gene is another important risk factor of gallstone formation after gastrectomy.

Explore further: Prosocial internet support group not beneficial for breast cancer

More information: Liu FL, Lu WB, Niu WX. XbaⅠ polymorphisms of apolipoprotein B gene: Another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol 2010; 16(20): 2549-2553. www.wjgnet.com/1007-9327/full/v16/i20/2549.htm

add to favorites email to friend print save as pdf

Related Stories

A case of post-gastrectomy acute pancreatitis

Oct 16, 2009

A clinical research team from Taiwan reported a case of asymptomatic pancreatic divisum who underwent palliative subtotal gastrectomy for an advanced gastric cancer with liver metastasis. They concluded for patients with ...

Recommended for you

Immune checkpoint inhibitors may work in brain cancers

Nov 21, 2014

New evidence that immune checkpoint inhibitors may work in glioblastoma and brain metastases was presented today by Dr Anna Sophie Berghoff at the ESMO Symposium on Immuno-Oncology 2014 in Geneva, Switzerland.

New model of follow up for breast cancer patients

Nov 21, 2014

Public health researchers from the University of Adelaide have evaluated international breast cancer guidelines, finding that there is potential to improve surveillance of breast cancer survivors from both a patient and health ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.