New book reviews research on key signaling molecule, NF-kB

May 25, 2010
The cover of "NF-kB: A Network Hub Controlling Immunity, Inflammation, and Cancer" illustrates canonical and non-canonical pathways for activating the transcription factor NF-kB. Credit: Cold Spring Harbor Laboratory Press

NF-κB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli.

A new book from Cold Spring Harbor Laboratory Press, NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer, summarizes the current state of research on NF-κB. It consists of 17 chapters and includes a historical introduction by David Baltimore, in whose lab NF-κB was discovered.

"The elucidation of NF-κB signaling in all of its molecular glory provided a new paradigm for understanding how receptor signaling can elicit transcriptional responses in mammalian cells," write the editors, Michael Karin and Louis M. Staudt, in the preface. "This collection includes reviews of the molecular mechanisms by which NF-κB transcription factors are activated and exert their function in the nucleus, as well as reviews that summarize certain realms of biology that are particularly influenced by NF-κB signaling."

The volume includes contributions covering the structure of NF-κB, its DNA-binding activity and specificity, the role of the inhibitor I-κB, and canonical and alternative mechanisms of NF-κB activation. The contributors examine the physiological role of NF-κB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-κB represents a critical link between inflammation and cancer, and describe clinical perspectives on the use of NF-κB inhibitors in cancer therapy.

NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer will be a vital reference for cell and molecular biologists, immunologists, and pathologists interested in the regulation of cell function.

Explore further: Study pinpoints microRNA tied to colon cancer tumor growth

add to favorites email to friend print save as pdf

Related Stories

A single protein regulates 2 immune pathways

Apr 29, 2010

Unchecked, the natural or innate immune system can run out of control - like a stuck accelerator on a car. Eventually, it will kill the host it is supposed to protect.

A paradigm shift in immune response regulation

Mar 19, 2009

Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together. Now, in Cell an international team reports a paradigm shift in the regulation of immune response. Their ...

Recommended for you

Study pinpoints microRNA tied to colon cancer tumor growth

2 hours ago

Researchers at the University of Minnesota have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer ...

Obesity tied to higher cancer risk for CRC survivors

4 hours ago

(HealthDay)—Colorectal cancer (CRC) patients who are overweight or obese when diagnosed appear to face a slightly higher risk for developing a second weight-related cancer, according to research published ...

User comments : 0