A potential therapeutic target for colon cancer

May 10, 2010

A research team from China investigated the association between peroxisome proliferator-activated receptor-γ (PPAR-γ) gene polymorphism 34 C>G and colorectal cancer (CRC) through a meta-analysis. They found PPAR-γ 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.

Colorectal cancer (CRC) is one of the major causes of cancer death in the developed countries. Accumulated evidences indicate that lipid metabolism, especially the one in the arachidonic acid (AA)-pathway, appears to play a critical role in the development of CRC. The peroxisome proliferator-activated receptor-γ(PPAR-γ) gene, one of the most important components of the AA-pathway, has been verified to express in a variety of tumor cells. Many studies have been performed about the association between the polymorphism 34 C>G of PPAR-γgene and CRC, but got conflicting results.

A research article to be published on May 7, 2010 in the World Journal of Gastroenterology addresses this question. A research team led by Professor Li-Cheng Dai, confirmed the former data of the association between PPAR-γgene 34 C>G and CRC in the meta-analysis.

In this report, the association between PPAR-γ gene 34 C>G and colon cancer risk was observed, and the G allele decreased the colon cancer risk, which is meaningful to early diagnosis, prevention and individual-based treatment of colon cancer. Furthermore, 34 C>G of PPAR-γ gene might be a potential therapeutic target for .

Explore further: Enzyme that silences DNA activity may be crucially involved in health and cancer

More information: Lu YL, Li GL, Huang HL, Zhong J, Dai LC. Peroxisome proliferator-activated receptor-γ 34C>G polymorphism and colorectal cancer risk: A meta-analysis. World J Gastroenterol 2010; 16(17): 2170-2175 www.wjgnet.com/1007-9327/full/v16/i17/2170.htm

add to favorites email to friend print save as pdf

Related Stories

Defective signaling pathway sheds light on cystic fibrosis

Feb 14, 2010

In a study that could lead to new therapeutic targets for patients with the cystic fibrosis, a research team from the University of California, San Diego School of Medicine has identified a defective signaling pathway that ...

A potential drug for liver carcinoma

May 22, 2009

Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, ...

Smoking can double risk of colorectal polyps

Feb 01, 2008

Smokers have a two-fold increased risk of developing colorectal polyps, the suspected underlying cause of most colorectal cancers (CRC), according to a study published in Gastroenterology, the official journal of the Americ ...

Recommended for you

Phase 3 study may be game-changer for acute myeloid leukemia

1 hour ago

Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia (AML) are very promising. Patients treated with CPX-351, a combination of the chemotherapeutic drugs cytarabine ...

User comments : 0

More news stories

Rising role seen for health education specialists

(HealthDay)—A health education specialist can help family practices implement quality improvement projects with limited additional financial resources, according to an article published in the March/April ...

FDA proposes first regulations for e-cigarettes

The federal government wants to prohibit sales of electronic cigarettes to minors and require approval for new products and health warning labels under regulations being proposed by the Food and Drug Administration.

When things get glassy, molecules go fractal

Colorful church windows, beads on a necklace and many of our favorite plastics share something in common—they all belong to a state of matter known as glasses. School children learn the difference between ...

FCC to propose pay-for-priority Internet standards

The Federal Communications Commission is set to propose new open Internet rules that would allow content companies to pay for faster delivery over the so-called "last mile" connection to people's homes.

SK Hynix posts Q1 surge in net profit

South Korea's SK Hynix Inc said Thursday its first-quarter net profit surged nearly 350 percent from the previous year on a spike in sales of PC memory chips.

Brazil enacts Internet 'Bill of Rights'

Brazil's president signed into law on Wednesday a "Bill of Rights" for the digital age that aims to protect online privacy and promote the Internet as a public utility by barring telecommunications companies ...