Highlight: Bacterial biofilms make the seeds of their own undoing

Apr 29, 2010

The slime on your shower walls, the plaque on your teeth, the coatings that can form on medical instruments or hospital surfaces--all of these are bacterial biofilms, communities of bacteria that can persist despite scrubbing or even antibiotic treatment.

New research shows that at least one type of , Bacillus subtilis, produces certain that actually prevent biofilm formation and trigger the breakdown of existing biofilms, researchers report in the April 30 issue of Science.

As biofilms age, their nutrient supply decreases, waste products accumulate, and it becomes more advantageous for the to return to their individual, free-floating forms.

Ilana Kolodkin-Gal and colleagues have found that B. subtilis bacteria secrete an unusual type of amino acid, D-amino acid, which releases them from the aging communities. D-amino acids, which are produced by many bacteria, may be a widespread signal for biofilm disassembly, according to the authors, who suggest that these amino acids could be useful in medical or industrial settings as anti-biofilm agents.

Explore further: Two-armed control of ATR, a master regulator of the DNA damage checkpoint

More information: "D-Amino Acids Trigger Biofilm Disassembly," by I. Kolodkin-Gal; Science, April 30.

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