Acellular dermal matrix and short bowel syndrome

Apr 28, 2010

Short bowel syndrome has puzzled surgeons for a long time and the curative effect are unsatisfactory. In recent years, acellular dermal matrix (ADM) has been used in many fields for tissue regeneration or scarless healing. A research group in China evaluated the efficacy of acellular dermal matrix for intestinal elongation in animal model. It seemed that ADM was not suited to using alone as a scaffold for the intestinal elongation.

Acellular dermal matrix (ADM) is a dermal biomaterial in which all of the cellular elements have been removed. The biologic properties of ADM, including its ability to support repopulation with fibroblasts, revascularization, new collagen deposition and eventual absorption and replacement with native tissue permit its use in tissue reconstruction. A few studies for intestinal elongation have been performed, but the results are uncertain.

The research, led by Professor Wang from Department of General Surgery of Beijing Chaoyang Hospital, will be published on April 28,2010 in . The study was designed to use both the home-made and commercial acellular dermal matrix materials to investigate the efficacy of acellular dermal matrix for intestinal elongation. Different species were transplanted with the allograft materials respectively. Severe adhesions were found between the graft and surrounding intestine. The grafts were completely absorbed within postoperative two or three months except one. Histological observation showed inflammation in the grafts with fibrinoid necroses, infiltration of a large amount of neutrophils and leukomonocytes, and the degree varied in different stage. The neointestine with well-formed structures wasn't observed in the study.

It is believed that the ADM can be used as a for tissue regeneration with the normal morphology of the mucosa, submucosa, muscle and serosa layers. But it is not always the truth. In this study, the grafts were almost completely absorbed in two or three months. Pus could be seen in the lumens of ADM and histological examination showed the inflammatory exudates of and pus cells. The authors presumed inadequate blood supply and the rapid absorption perhaps were the most likely reasons.

This study was well designed according to previous work, but it showed a different result. The authors gave some possible reasons, which were worthy of in-depth study. Perhaps ADM can be used for intestinal elongation, but this study showed that some reforms were necessary.

Explore further: Global Ebola conference seeks end to W.Africa outbreak

More information: Xu HM, Wang ZJ, Han JG, Ma HC, Zhao B, Zhao BC. Application of acellular dermal matrix for intestinal elongation in animal models. World J Gastroenterol 2010; 16(16): 2023-2027, www.wjgnet.com/1007-9327/full/v16/i16/2023.htm

add to favorites email to friend print save as pdf

Related Stories

Researchers identify new stem cell

Dec 07, 2009

(PhysOrg.com) -- Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described ...

Study uses bone marrow stem cells to regenerate skin

Jan 14, 2009

A new study suggests that adult bone marrow stem cells can be used in the construction of artificial skin. The findings mark an advancement in wound healing and may be used to pioneer a method of organ reconstruction. The ...

New materials developed for vascular graft

Jun 14, 2006

Virginia Commonwealth University engineers and scientists have developed a new material that may one day help patients with damaged arteries regenerate new ones.

Recommended for you

Global Ebola conference seeks end to W.Africa outbreak

3 hours ago

Leaders of Ebola-hit countries in west Africa will attend an international conference in Brussels Tuesday to mobilise a final push to end the outbreak and ensure the delivery of nearly $5 billion in aid pledges.

High prevalence of HCV in baby boomers presenting to ER

12 hours ago

(HealthDay)—The prevalence of unrecognized chronic hepatitis C virus (HCV) is high among baby boomers presenting to the emergency department, according to a study published online Jan. 28 in Hepatology.

The hidden burden of dengue fever in West Africa

13 hours ago

Misdiagnosis of febrile illnesses as malaria is a continuing problem in Africa. A new study shows that in Ghana, dengue fever is circulating in urban areas and going undiagnosed. The authors of the study hope to use the findings ...

Teenager with stroke symptoms actually had Lyme disease

13 hours ago

A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease. The highly unusual case presentation was published ...

Understanding lung disease in aboriginal Australians

15 hours ago

A new study has confirmed that Aboriginal Australians have low forced vital capacity—or the amount of air that can be forcibly exhaled from the lungs after taking the deepest breath possible. The finding may account for ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.