Toward a urine test for detecting colon cancer

Apr 21, 2010
Cancer of the colon, the orange structure highlighted in this computerized image, may be detected by doctors in the future using a simple urine test. Credit: iStock

Scientists are reporting an advance toward development of a urine test for detecting colon cancer, the third most common cancer in the United States. Such a test could eventually compliment or even reduce the need for colonoscopy, the mainstay screening test used today. The study, which analyzes chemical differences in the urine of humans with and without colon cancer, is in ACS' Journal of Proteome Research, a monthly publication.

Wei Jia and colleagues point out that colonoscopy, which involves using a flexible, lighted tube to see inside the colon, is the most effective tool for the early screening of colon cancer. However, the procedure is unpleasant, costly, and time-consuming. A urine test could provide an alternative method, the scientists say.

The scientists analyzed urine samples from 123 people — 60 with colon cancer and 63 without — for differences in its composition. They identified 16 substances that appear in unusual amounts in colon cancer. The changes include increased levels of tryptophan, one of the 22 that are found in proteins. The results demonstrate the potential of using urine as a tool for diagnosing , the scientists say.

Explore further: Space-tested fluid flow concept advances infectious disease diagnoses

More information: "Urinary Metabonomic Study on Colorectal Cancer", Journal of Proteome Research.

add to favorites email to friend print save as pdf

Related Stories

New biomarkers for predicting the spread of colon cancer

Jan 13, 2010

Scientists in China are reporting discovery of two proteins present in the blood, of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. ...

Heart drugs show promise for fighting colon cancer

Dec 16, 2009

Scientists in Sweden are reporting for the first time that a group of drugs used to treat heart failure shows promise for fighting colon cancer. The study is in ACS' Journal of Natural Products. Colon cancer ...

Recommended for you

User comments : 0

More news stories

NASA's space station Robonaut finally getting legs

Robonaut, the first out-of-this-world humanoid, is finally getting its space legs. For three years, Robonaut has had to manage from the waist up. This new pair of legs means the experimental robot—now stuck ...

Ex-Apple chief plans mobile phone for India

Former Apple chief executive John Sculley, whose marketing skills helped bring the personal computer to desktops worldwide, says he plans to launch a mobile phone in India to exploit its still largely untapped ...

Filipino tests negative for Middle East virus

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

Egypt archaeologists find ancient writer's tomb

Egypt's minister of antiquities says a team of Spanish archaeologists has discovered two tombs in the southern part of the country, one of them belonging to a writer and containing a trove of artifacts including reed pens ...