Toward a urine test for detecting colon cancer

Apr 21, 2010
Cancer of the colon, the orange structure highlighted in this computerized image, may be detected by doctors in the future using a simple urine test. Credit: iStock

Scientists are reporting an advance toward development of a urine test for detecting colon cancer, the third most common cancer in the United States. Such a test could eventually compliment or even reduce the need for colonoscopy, the mainstay screening test used today. The study, which analyzes chemical differences in the urine of humans with and without colon cancer, is in ACS' Journal of Proteome Research, a monthly publication.

Wei Jia and colleagues point out that colonoscopy, which involves using a flexible, lighted tube to see inside the colon, is the most effective tool for the early screening of colon cancer. However, the procedure is unpleasant, costly, and time-consuming. A urine test could provide an alternative method, the scientists say.

The scientists analyzed urine samples from 123 people — 60 with colon cancer and 63 without — for differences in its composition. They identified 16 substances that appear in unusual amounts in colon cancer. The changes include increased levels of tryptophan, one of the 22 that are found in proteins. The results demonstrate the potential of using urine as a tool for diagnosing , the scientists say.

Explore further: Celebrating 100 years of crystallography

More information: "Urinary Metabonomic Study on Colorectal Cancer", Journal of Proteome Research.

add to favorites email to friend print save as pdf

Related Stories

New biomarkers for predicting the spread of colon cancer

Jan 13, 2010

Scientists in China are reporting discovery of two proteins present in the blood, of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. ...

Heart drugs show promise for fighting colon cancer

Dec 16, 2009

Scientists in Sweden are reporting for the first time that a group of drugs used to treat heart failure shows promise for fighting colon cancer. The study is in ACS' Journal of Natural Products. Colon cancer ...

Recommended for you

The fluorescent fingerprint of plastics

10 hours ago

LMU researchers have developed a new process which will greatly simplify the process of sorting plastics in recycling plants. The method enables automated identification of polymers, facilitating rapid separation ...

Water and sunlight the formula for sustainable fuel

14 hours ago

An Australian National University (ANU) team has successfully replicated one of the crucial steps in photosynthesis, opening the way for biological systems powered by sunlight which could manufacture hydrogen ...

Rice chemist wins 'Nobel Prize of Cyprus'

14 hours ago

Rice University organic chemist K.C. Nicolaou has earned three prestigious international honors, including the Nemitsas Prize, the highest honor a Cypriot scientist can receive and one of the most prestigious ...

Researchers create engineered energy absorbing material

16 hours ago

(Phys.org) —Materials like solid gels and porous foams are used for padding and cushioning, but each has its own advantages and limitations. Gels are effective as padding but are relatively heavy; gel performance ...

User comments : 0