Increased EGFR levels may be an early marker of breast cancer

Apr 20, 2010

Levels of epidermal growth factor receptor (EGFR) may be elevated in the blood of women within 17 months prior to their breast cancer diagnosis, according to findings presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here April 17-21.

The goal of the study led by Christopher Li, M.D., Ph.D., an associate member of the Epidemiology Program at the Fred Hutchinson Cancer Research Center, Seattle, was to discover and validate blood markers that could potentially be used for the early detection of breast cancer.

The study was conducted on 420 estrogen receptor-positive breast cancer patients whose blood was drawn within 17 months prior to their cancer diagnosis. The researchers validated promising markers in a similar, but completely independent set of 198 cases and controls from the Women's Health Initiative database.

One of the promising markers that was discovered and could be validated was EGFR.

EGFR levels were significantly elevated among cases compared to controls. Overall, those with the highest levels had a 2.9-fold increased risk of developing breast cancer compared to those with the lowest level.

When EGFR levels were evaluated among current users of hormone therapy, a much larger ninefold increased risk of developing breast cancer was observed. As a single marker among current estrogen plus progestin users, EGFR had a specificity, the rate of true negative tests, of 90 percent and a sensitivity, the rate of true positive tests, of 31 percent as a breast cancer marker.

"While our results require confirmation and EGFR's performance is insufficient for it to be used as a single marker, this study is unique in that no prior studies have validated a single breast cancer early detection biomarker specimen to the degree we have here," said Li. "Our results suggest that there may indeed be detectable changes of proteins in blood within two years of making a clinical breast cancer diagnosis. Identification of these proteins could have a major impact on our ability to detect breast cancer early, when it is most treatable."

EGFR is part of the HER2 family, which has been shown to be quite important in . Specifically, increased EGFR activity can increase the uncontrolled growth of cancer cells and EGFR is elevated in 20 percent to 81 percent of all human breast cancers. Several therapies targeting members of the HER2 family, including EGFR, have already been approved for cancer treatment.

Explore further: Natural products from plants protect skin during cancer radiotherapy

add to favorites email to friend print save as pdf

Related Stories

Hormone therapy raises cancer risk

Jan 16, 2008

Menopausal women who take hormone combinations for their symptoms are more likely to get an uncommon type of breast cancer much earlier than experts believed.

Estrogen therapy increases benign breast disease risk

Apr 08, 2008

Women who took conjugated equine estrogen, a commonly prescribed form of estrogen, had more than twice the risk of developing specific types of benign breast disease as women who took a placebo, according to a randomized ...

Recommended for you

All-clear for nonlinear optical imaging

2 hours ago

High power femto-second laser pulses used for in vivo nonlinear optical imaging can form DNA products, which may lead to carcinogenesis. A modified cancer risk model now shows that the cancer risk is negligible ...

Pain and itch may be signs of skin cancer

18 hours ago

Asking patients if a suspicious skin lesion is painful or itchy may help doctors decide whether the spot is likely to be cancerous, according to a new study headed by Gil Yosipovitch, MD, Chairman of the Department of Dermatology ...

User comments : 0