Bloome syndrome protein is critical for meiotic recombination

Mar 22, 2010

Researchers from Cornell University (NY) provide the first analysis of the function of Bloome syndrome protein (BLM) in mammalian meiosis. Bloome syndrome (BS) is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM.

The study appears in the March 22 issue of the .

Although BLM has been shown to play an important role in DNA recombination in somatic cells, there has been no information on the impact of BLM in mammalian meiosis. Now, a team led by Paula Cohen provides new data that indicate mouse BLM is involved in the proper pairing, synapsis, and segregation of homologous during meiosis, but does not affect entry into the prophase I stage.

Explore further: Researchers produce first atlas of airborne microbes across United States

More information: Holloway, J.K., et al. 2010. J. Cell Biol. doi:10.1083/jcb.200909048.

Related Stories

Bureau of Land Management is criticized

Feb 22, 2006

The U.S. Bureau of Land Management is being accused of focusing on oil drilling and ignoring the affect such drilling might have on wildlife.

New insight into Bloom's syndrome

Oct 14, 2008

Two independent papers in the October 15th issue of G&D detail the discovery of a previously unidentified fourth component of the Bloom's syndrome complex.

Recommended for you

Vascular cells can fuse with themselves

21 hours ago

Cells of the vascular system of vertebrates can fuse with themselves. This process, which occurs when a blood vessel is no longer necessary and pruned, has now been described on the cellular level by Prof. ...

Key element in bacterial immune system discovered

21 hours ago

A University of Otago scientist is a member of an international research team that has made an important discovery about the workings of a bacterial immune system. The finding could lead to the development ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.