Vitamin B6 ingredient linked to lower colorectal cancer risk: study

Mar 16, 2010

Vitamin B6 appears to play a beneficial role in preventing colon cancer, a study published Tuesday concluded.

Researchers led by Susanna Larsson of Sweden's National Institute of Environmental medicine traced the beneficial effects to pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6.

"Vitamin B6 intake and blood PLP levels were inversely related with the risk of colorectal cancer," the study said.

Vitamin B6 is found in cereals, vegetables, poultry and fish as well as in some fruits like bananas and avocados.

Published in a special edition of the Journal of American Medical Association, the study analyzed 13 other US, European and Asian studies conducted between 2002 and 2009.

In the United States, according to JAMA, 20 percent of men and 40 percent of women over the age of 50 do not take in sufficient vitamin B6.

While taking vitamin B6 supplements did not appear to reduce the risk of colorectal cancer, increases in the level of PLP in the were associated with an inversely lower risk of colorectal cancer.

The authors believe that these studies could contain distortions because individuals who take vitamin B6 tend to have healthy behavior, such as less smoking and alcohol and higher .

But studies that compared the effects of taking weak to high doses of vitamin B6 also showed "a statistically significant 21 percent reduction in risk" at higher doses.

Explore further: Six percent of colorectal cancer found to be interval tumors

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