Researchers One Step Closer to Understanding Underlying Causes of Cancer and Diabetes

Mar 10, 2010

(PhysOrg.com) -- A Saskatchewan Cancer Agency researcher and her team have discovered a new link between the "on" and "off" switches that control cell growth and insulin responses in the body. This work could have implications for cancer and diabetes treatment.

The p85 protein is known to control the “on switch” for cell division and if it is too active, can result. This “on switch” is also important for cells to respond to and if it is not active enough insulin-insensitive can result.

The new discovery, published this week in the , shows that p85 can also control the “off switch” for these responses.

“By understanding the connection between the switches that control cell responses for growth and insulin we are able to improve our ability to use anti-cancer therapies to target these switches more effectively,” said Deborah Anderson, Senior Research Scientist with the Saskatchewan Cancer Agency and a cross appointment in oncology and biochemistry at the University of Saskatchewan.

Funding for this research originally came from the Canadian Institutes of Health Research (CIHR) Regional Partnership Program - Saskatchewan (RPP-SK), with matching funding from the Saskatchewan Health Research Foundation (SHRF).

Explore further: New method for reducing tumorigenicity in induced pluripotent stem-cell based therapies

Provided by Saskatchewan Cancer Agency

4.5 /5 (2 votes)
add to favorites email to friend print save as pdf

Related Stories

Exercise pivotal in preventing and fighting type II diabetes

Feb 07, 2007

One in three American children born in 2000 will develop type II diabetes, according to the U.S. Centers for Disease Control and Prevention (CDC). A new study at the University of Missouri-Columbia says that acute exercise ...

Recommended for you

Intestinal parasites are 'old friends,' researchers argue

1 hour ago

Intestinal parasites such as tapeworms, hookworms and a protist called Blastocystis can be beneficial to human health, according to a new paper that argues we should rethink our views of organisms that live off the human ...

Researchers unlock the protein puzzle

1 hour ago

By using brightly hued dyes, George Mason University researchers discovered an innovative way to reveal where proteins touch each other, possibly leading to new treatments for cancer, arthritis, heart disease and even lung ...

Scientists image a beating heart in 3D (w/ Video)

3 hours ago

Researchers of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden report how they managed to capture detailed three-dimensional images of cardiac dynamics in zebrafish. The novel approach: ...

User comments : 0