Heat therapy shown effective in treating cutaneous leishmaniasis among US soldiers in Iraq

Mar 09, 2010

A single session of heat therapy using the ThermoMed device appears to be as effective as a 10-day intravenous course of sodium stibogluconate (Pentostam) for the treatment of Leishmania major skin lesions, according to a new study by Naomi Aronson and her colleagues at the Uniformed Services University of the Health Sciences and Walter Reed Army Medical Center (WRAMC).

Results from the randomized treatment trial, which involved 56 military personnel who contracted L. major while serving in Iraq, are reported March 5 in the open-access journal PLoS Neglected Tropical Diseases.

Cutaneous leishmaniasis is endemic to Iraq and Afghanistan, and more than 1,300 American military and civilian personnel have developed the parasitic since operations have commenced in these countries. Initially, the primary treatment option was evacuation to WRAMC for sodium stibogluconate treatment under an investigational drug protocol. Aronson and colleagues therefore tested the efficacy of the ThermoMed device, a potential tool for on-site treatment.

The patients treated in the study received either a single session with the ThermoMed device or a daily intravenous infusion of sodium stibogluconate, a pentavalent antimony drug, over a period of 10 days. They were then checked at two-, six-, and 12-month intervals to assess the healing process. Both treatments resulted in comparable rates of healing and, though the number and severity of the side effects were greater with sodium stibogluconate treatment, these resolved over time without long-term effect.

Aronson and colleagues suggest that a rugged, battery-operated device such as the ThermoMed, which could be forward-deployed in the field to effectively treat L. major , is not just operationally significant for the military, but may offer non-governmental agencies another method of treatment for cutaneous leishmaniasis.

Explore further: Researchers discover target for treating dengue fever

add to favorites email to friend print save as pdf

Related Stories

Injury severity linked with PTSD

Oct 03, 2006

U.S. scientists say the severity of injuries suffered by soldiers in Iraq and Afghanistan can predict posttraumatic stress disorder and depression risks.

Recommended for you

Vietnam battles fatal measles outbreak

2 hours ago

Vietnam is scrambling to contain a deadly outbreak of measles that has killed more than 100 people, mostly young children, and infected thousands more this year, the government said Friday.

Researchers discover target for treating dengue fever

18 hours ago

Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other ...

User comments : 0

More news stories

Vietnam battles fatal measles outbreak

Vietnam is scrambling to contain a deadly outbreak of measles that has killed more than 100 people, mostly young children, and infected thousands more this year, the government said Friday.

Continents may be a key feature of Super-Earths

Huge Earth-like planets that have both continents and oceans may be better at harboring extraterrestrial life than those that are water-only worlds. A new study gives hope for the possibility that many super-Earth ...

Researchers successfully clone adult human stem cells

(Phys.org) —An international team of researchers, led by Robert Lanza, of Advanced Cell Technology, has announced that they have performed the first successful cloning of adult human skin cells into stem ...

Under some LED bulbs whites aren't 'whiter than white'

For years, companies have been adding whiteners to laundry detergent, paints, plastics, paper and fabrics to make whites look "whiter than white," but now, with a switch away from incandescent and fluorescent lighting, different ...