Dialysis patients: Fatigue may predict heart attack

Feb 26, 2010

For dialysis patients, high scores on a new fatigue rating scale predict an increased risk of heart attack or other cardiovascular events, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).

Fatigue could be an important warning sign of serious cardiovascular events—especially
in patients without other obvious risk factors, according to the study led by Hidenori Koyama, MD, PhD, and Yoshiki Nishizawa, MD, PhD (Osaka City University Graduate School of Medicine, Japan). "Our data highlight for the first time the pathophysiological significance of fatigue as an important bio-alarm for ," Koyama
comments.

The researchers evaluated their fatigue questionnaire in a group of 788 dialysis patients. Fatigue is one of the most common symptoms experienced by dialysis patients.

About 16 percent of the dialysis patients had a high fatigue score. At two years' followup, patients with high fatigue scores were more than twice as likely to have cardiovascular events such as a heart attack () or stroke.

A key feature of the new fatigue questionnaire was that it differentiated fatigue from the
many factors associated with it, such as anxiety and depression, pain, overwork, or infection. Fatigue itself was the strongest predictor of , even in
patients without known risk factors, such as malnutrition, diabetes, and previous cardiovascular disease.

Recent studies have shown that fatigue and other behavioral and have important links to cardiovascular diseases. However, there is still very limited
information on how fatigue affects the risk of cardiovascular disease.

"Our research identifies fatigue as an important bio-alarm to predict cardiovascular events in , particularly those who are well-nourished and healthy-looking,"
according to Koyama. The researchers believe the new questionnaire will be useful in understanding not only fatigue itself, but also the causative factors contributing to it.

They call for further research to determine whether objective measures of fatigue can predict cardiovascular events and to understand the mechanisms underlying this relationship. "Another important question is whether interventions for fatigue will be effective in preventing cardiovascular events," Koyama adds.

Explore further: Study shows Tamiflu gets patients back on their feet faster, reduces flu complications

More information: The article, entitled "Fatigue Is a Predictor for Cardiovascular Outcomes in Patients Undergoing Hemodialysis," will appear online on February 25, 2010, doi 10.2215/CJN.08151109

add to favorites email to friend print save as pdf

Related Stories

Anemia drug not helpful for kidney disease patients

Dec 22, 2009

An international study authored by a UT Southwestern Medical Center researcher has concluded that the anemia drug darbepoetin alfa works no better than a placebo in several other applications previously thought to be promising.

Childhood trauma associated with chronic fatigue syndrome

Jan 05, 2009

Individuals who experience trauma during childhood appear more likely to develop chronic fatigue syndrome as adults, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals. In ...

Recommended for you

Kidney-brain connection may help drive chronic kidney disease

9 hours ago

In addition to affecting blood pressure, high-salt intake can promote kidney function decline in patients with chronic kidney disease. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (J ...

Flu's grip on U.S. starting to weaken: CDC

10 hours ago

(HealthDay)—After a rough start to the flu season, the number of infections seems to have peaked and is even starting to decline in many parts of the nation, federal health officials reported Thursday.

Litchi fruit suspected in mystery illness in India

10 hours ago

A mysterious and sometimes fatal brain disease that has afflicted children in northeastern India for years could be linked to a toxic substance in litchi fruits, US researchers said Thursday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.