Dialysis patients: Fatigue may predict heart attack

Feb 26, 2010

For dialysis patients, high scores on a new fatigue rating scale predict an increased risk of heart attack or other cardiovascular events, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).

Fatigue could be an important warning sign of serious cardiovascular events—especially
in patients without other obvious risk factors, according to the study led by Hidenori Koyama, MD, PhD, and Yoshiki Nishizawa, MD, PhD (Osaka City University Graduate School of Medicine, Japan). "Our data highlight for the first time the pathophysiological significance of fatigue as an important bio-alarm for ," Koyama
comments.

The researchers evaluated their fatigue questionnaire in a group of 788 dialysis patients. Fatigue is one of the most common symptoms experienced by dialysis patients.

About 16 percent of the dialysis patients had a high fatigue score. At two years' followup, patients with high fatigue scores were more than twice as likely to have cardiovascular events such as a heart attack () or stroke.

A key feature of the new fatigue questionnaire was that it differentiated fatigue from the
many factors associated with it, such as anxiety and depression, pain, overwork, or infection. Fatigue itself was the strongest predictor of , even in
patients without known risk factors, such as malnutrition, diabetes, and previous cardiovascular disease.

Recent studies have shown that fatigue and other behavioral and have important links to cardiovascular diseases. However, there is still very limited
information on how fatigue affects the risk of cardiovascular disease.

"Our research identifies fatigue as an important bio-alarm to predict cardiovascular events in , particularly those who are well-nourished and healthy-looking,"
according to Koyama. The researchers believe the new questionnaire will be useful in understanding not only fatigue itself, but also the causative factors contributing to it.

They call for further research to determine whether objective measures of fatigue can predict cardiovascular events and to understand the mechanisms underlying this relationship. "Another important question is whether interventions for fatigue will be effective in preventing cardiovascular events," Koyama adds.

Explore further: Evidence-based recs issued for systemic care in psoriasis

More information: The article, entitled "Fatigue Is a Predictor for Cardiovascular Outcomes in Patients Undergoing Hemodialysis," will appear online on February 25, 2010, doi 10.2215/CJN.08151109

add to favorites email to friend print save as pdf

Related Stories

Anemia drug not helpful for kidney disease patients

Dec 22, 2009

An international study authored by a UT Southwestern Medical Center researcher has concluded that the anemia drug darbepoetin alfa works no better than a placebo in several other applications previously thought to be promising.

Childhood trauma associated with chronic fatigue syndrome

Jan 05, 2009

Individuals who experience trauma during childhood appear more likely to develop chronic fatigue syndrome as adults, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals. In ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

9 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

9 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

9 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

12 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

13 hours ago

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.