Genomic warfare to counter malaria drug resistance

Feb 16, 2010

Scientists battling malaria have earned a major victory. According to a Nature Genetics study, an international group of researchers has used genomics to decode the blueprint of Plasmodium falciparum - a strain of malaria most resistant to drugs that causes the most deaths around the world. The discovery may lead to advanced pharmaceuticals to fight the disease and prevent drug resistance among the 250 million people infected by malaria each year.

"Combating resistance is nothing short of an arms race," says lead author Dr. Philip Awadalla, a pediatrics professor at the Université de Montréal, a scientist at the Sainte-Justine University Hospital Research Center and scientific director of CARTaGENE. "As the malaria pathogen evolves, researchers must evolve with it to find ways to counter the disease."

The team decoded 200 malaria samples from Asia, Africa, Central America, South America and Papua New Guinea. Their goal was to identify how strains were becoming resistant to the eight anti-malaria drugs currently available.

"There are substantial genetic differences in malaria around the world," stresses Dr. Awadalla, noting African strains differ from Asia strains. "What has occurred is a combination of genetic drift, where genes segregated over space and time from differential environments, immune pressures and exposures to drugs."

As part of their genomic mapping, the research team found that Plasmodium falciparum recombined fastest in Africa. Dr. Awadalla compares malaria genomes to human genomes. In malaria, however, variation among some genetic material is so high and evolves so rapidly that the parasite can develop .

New clues garnered by this study, he says, "will allow pharmaceutical companies to create treatments that target the evolving malaria genome."

Explore further: Assortativity signatures of transcription factor networks contribute to robustness

More information: The article "Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs" is published in the journal Nature. www.nature.com/ng/journal/vaop… ent/full/ng.528.html

add to favorites email to friend print save as pdf

Related Stories

Discovery provides new drug targets for malaria cure

Jan 11, 2010

Researchers are a step closer to developing new antimalarial drugs after discovering the normal function of a set of proteins related to the malaria parasite protein, which causes resistance to the front-line drug chloroquine. ...

Malaria top killer in Congo

Apr 30, 2008

Health officials in the Democratic Republic of Congo say malaria is the primary cause of illness and death, despite prevention efforts.

Recommended for you

Mutation disables innate immune system

Aug 29, 2014

A Ludwig Maximilian University of Munich team has shown that defects in the JAGN1 gene inhibit the function of a specific type of white blood cells, and account for a rare congenital immune deficiency that ...

Study identifies genetic change in autism-related gene

Aug 28, 2014

A new study from Bradley Hospital has identified a genetic change in a recently identified autism-associated gene, which may provide further insight into the causes of autism. The study, now published online in the Journal of ...

NIH issues finalized policy on genomic data sharing

Aug 27, 2014

The National Institutes of Health has issued a final NIH Genomic Data Sharing (GDS) policy to promote data sharing as a way to speed the translation of data into knowledge, products and procedures that improve health while ...

The genes behind the guardians of the airways

Aug 27, 2014

Dysfunctions in cilia, tiny hair-like structures that protrude from the surface of cells, are responsible for a number of human diseases. However the genes involved in making cilia have remained largely elusive. ...

User comments : 0