Insulin research points way to better diabetes treatments

Jan 25, 2010

New research that significantly improves our understanding of how insulin interacts with cells in the human body is published today.

The study could have major implications for the development of treatments for Type I diabetes.

By developing and analysing a range of super active insulins, scientists from the York Structural Biology Laboratory at the University of York have been able to identify common features that point to the likely of human insulin when it is active in the body.

The research also offers new insight into how insulin binds to insulin receptors on cells.

The research was conducted with colleagues at the Institute of and Biochemistry of the Academy of Sciences of the Czech Republic, and is published in the journal .

Dr Marek Brzozowski, from the York Structural Biology Laboratory, said: "The structures of inactive forms of insulin and the insulin receptor are reasonably well known, but documenting how they interact has proven to be a considerable scientific challenge.

"Improving our understanding of this interaction holds the key to developing far more sophisticated treatments for Type I diabetes and this research represents an important step forward."

The research could help the development of insulin treatments that can be more carefully controlled or that could be delivered without the need for injections.

Explore further: Nigeria death shows Ebola can spread by air travel

Provided by University of York

4 /5 (3 votes)

Related Stories

Exercise pivotal in preventing and fighting type II diabetes

Feb 07, 2007

One in three American children born in 2000 will develop type II diabetes, according to the U.S. Centers for Disease Control and Prevention (CDC). A new study at the University of Missouri-Columbia says that acute exercise ...

How does insulin influence resistin?

Jan 16, 2008

Obesity is a worldwide health problem directly linked to several diseases such as hypertension and type 2 diabetes. Resistin is a cysteine-rich hormone mainly secreted by adipose tissues and may form a biochemical link between ...

Impaired fat-burning gene worsens diabetes

Feb 07, 2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people ...

Recommended for you

Nigeria death shows Ebola can spread by air travel

11 hours ago

(AP)—Nigerian health authorities raced to stop the spread of Ebola on Saturday after a man sick with one of the world's deadliest diseases brought it by plane to Lagos, Africa's largest city with 21 million ...

Trial in salmonella outbreak to start in Georgia

11 hours ago

(AP)—Three people accused of scheming to manufacture and ship salmonella-tainted peanuts that killed nine people and sickened more than 700 are set to go to trial this week in Georgia.

Remote tribe members enter another village, catch flu

19 hours ago

Advocates for indigenous tribes are worried over incidents last month when some members of one of the last uncontacted tribes in the Peru/Brazil region, across borders, left their home in Peru and entered ...

Nigeria on red alert after first Ebola death

Jul 26, 2014

Nigeria was on alert against the possible spread of Ebola on Saturday, a day after the first confirmed death from the virus in Lagos, Africa's biggest city and the country's financial capital.

User comments : 0