Prognosis of intrahepatic cholangiocarcinoma

Jan 15, 2010

Incidence of intrahepatic cholangiocarcinoma (ICC) is increasing worldwide and its prognosis is very poor. Thus, further studies on its clinical characteristics for early detection and on surgical treatment for better prognosis are urgently needed.

A research team from China retrospectively evaluated 5311 liver cancer patients who received resection between October 1999 and December 2003. Of these, 429 (8.1%) patients were diagnosed with ICC, and their clinicopathological, surgical, and survival characteristics were analyzed. Their study will be published on December 21, 2009 in the World Journal of Gastroenterology.

Their research demonstrated that infection, carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and a-fetoprotein (AFP) are associated with ICC development. CA19-9 levels are associated with lymph node , but inversely with cirrhosis. Radical resection (R0) is the key prognostic factor for ICC. Future studies should focus on evaluation of the molecule-targeted therapy, and whether it can efficiently control this deadly disease so as to improve the survival of the patients.

Explore further: Early hormone therapy may be safe for women's hearts

More information: Shen WF, Zhong W, Xu F, Kan T, Geng L, Xie F, Sui CJ, Yang JM. Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma. World J Gastroenterol 2009; 15(47): 5976-5982 www.wjgnet.com/1007-9327/15/5976.asp

add to favorites email to friend print save as pdf

Related Stories

A new molecular marker of gastric cancer

Mar 30, 2009

Gastric cancer (GC) is one of the most common malignancies in the world with a high incidence and death rate. TNM staging system is used worldwide to predict prognosis and direct therapeutic decisions of patients with GC. ...

Molecules may help predict survival in liver cancer

Jan 30, 2008

Tiny molecules that help cells regulate which proteins they make might one day help doctors predict which liver-cancer patients are likely to live longer than others, new research suggests.

Recommended for you

Early hormone therapy may be safe for women's hearts

6 hours ago

(HealthDay)—Healthy women at low risk of cardiovascular disease may be able to take hormone replacement therapy soon after menopause for a short time without harming their hearts, according to a new study.

Low yield for repeat colonoscopy in some patients

7 hours ago

(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to patients who had no polyps found on adequate examination; however, repeat colonoscopies do benefit patients when the baseline examination was compromised, ...

Cell's recycling center implicated in division decisions

10 hours ago

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified ...

User comments : 0