Dead Sea-dwelling microbes reveal roots of protein common to all higher life forms

Jan 11, 2010 by Stu Hutson

(PhysOrg.com) -- We have more in common with Dead Sea-dwelling microbes than previously thought. University of Florida researchers have found that one of the most common proteins in complex life forms may have evolved from proteins found in microbes that live in deadly salty environments.

We have more in common with Dead Sea-dwelling than previously thought. University of Florida researchers have found that one of the most common proteins in complex life forms may have evolved from proteins found in microbes that live in deadly salty environments.

The protein ubiquitin is so-called because it is ubiquitously active in all higher life forms on Earth. The protein is essential to the life cycle of nearly all eukaryotic cells — those that are complex enough to have a nucleus and other membrane-bound structures.

Haloferax volcanii microbes, on the other hand, are unique creatures. One of the most on the planet, they long ago adapted to conditions far too salty for other organisms — even surviving for thousands of years in dried-out salt lakes.

As they report in the Jan. 7 issue of the journal Nature, researchers for UF’s Institute of Food and Agricultural Sciences have found that two proteins in Haloferax are likely the simple evolutionary precursors of ubiquitin.

These two proteins, dubbed SAMP1 and SAMP2, seem to perform similar functions to ubiquitin without some of enzymes that are needed for ubiquitin to function in eukaryotes, said Julie Maupin-Furlow, the study’s lead researcher and professor in UF’s department of microbiology and cell science.

The finding not only lends insight into how ubiquitin evolved, but it also reveals that this seemingly complex may have some simple mechanisms that can be examined for use as potential medical treatments, Maupin-Furlow said.

Researchers are currently investigating ’s role in a broad range of diseases such as cancer, , neurodegenerative disorders, muscle wasting, diabetes and various inflammatory conditions.

“This opens the door to a new avenue of study for this very important protein,” Maupin-Furlow said. “And it gives us a broader picture of some of the common aspects of life on Earth.”

Explore further: Researchers successfully clone adult human stem cells

Related Stories

Team finds most complex protein knot ever seen

Sep 20, 2006

An MIT team has discovered the most complicated knot ever seen in a protein, and they believe it may be linked to the protein's function as a rescue agent for proteins marked for destruction.

New protein identified in bacterial arsenal

Mar 03, 2009

(PhysOrg.com) -- Nearly a billion years ago, bacteria evolved an insidious means of infecting their hosts — a syringe-like mechanism able to inject cells with stealthy hijacker molecules. These molecules, ...

When proteins change partners

Sep 11, 2009

Dieter Wolf, M.D., and colleagues at Burnham Institute for Medical Research (Burnham) have illuminated how competition between proteins enhances combinatorial diversity during ubiquitination (the process that marks proteins ...

Researchers identify a scaffold regulating protein disposal

Dec 11, 2009

How does a cell manage to identify and degrade the diverse types of defective proteins and thus protect the body against serious diseases? The researchers Sabine C. Horn, Professor Thomas Sommer, Professor Udo Heinemann and ...

Recommended for you

Researchers successfully clone adult human stem cells

4 hours ago

(Phys.org) —An international team of researchers, led by Robert Lanza, of Advanced Cell Technology, has announced that they have performed the first successful cloning of adult human skin cells into stem ...

Researchers develop new model of cellular movement

7 hours ago

(Phys.org) —Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of ...

For resetting circadian rhythms, neural cooperation is key

Apr 17, 2014

Fruit flies are pretty predictable when it comes to scheduling their days, with peaks of activity at dawn and dusk and rest times in between. Now, researchers reporting in the Cell Press journal Cell Reports on April 17th h ...

User comments : 0

More news stories

Plants with dormant seeds give rise to more species

Seeds that sprout as soon as they're planted may be good news for a garden. But wild plants need to be more careful. In the wild, a plant whose seeds sprouted at the first warm spell or rainy day would risk disaster. More ...

Researchers successfully clone adult human stem cells

(Phys.org) —An international team of researchers, led by Robert Lanza, of Advanced Cell Technology, has announced that they have performed the first successful cloning of adult human skin cells into stem ...

Researchers develop new model of cellular movement

(Phys.org) —Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of ...

Male monkey filmed caring for dying mate (w/ Video)

(Phys.org) —The incident was captured by Dr Bruna Bezerra and colleagues in the Atlantic Forest in the Northeast of Brazil.  Dr Bezerra is a Research Associate at the University of Bristol and a Professor ...

LinkedIn membership hits 300 million

The career-focused social network LinkedIn announced Friday it has 300 million members, with more than half the total outside the United States.

Magnitude-7.2 earthquake shakes Mexican capital

A powerful magnitude-7.2 earthquake shook central and southern Mexico on Friday, sending panicked people into the streets. Some walls cracked and fell, but there were no reports of major damage or casualties.

Sun emits a mid-level solar flare

The sun emitted a mid-level solar flare, peaking at 9:03 a.m. EDT on April 18, 2014, and NASA's Solar Dynamics Observatory captured images of the event. Solar flares are powerful bursts of radiation. Harmful ...