Catheter ablation prior to defibrillator shock reduces risk of recurrence of life threatening rapid heartbeat

Jan 01, 2010

Patients with episodes of ventricular tachycardia (VT—a rapid heartbeat that originates in the ventricles) are at high risk of repeat VT, ventricular fibrillation, and death. Use of an implantable cardioverter defibrillator (ICD), reduces mortality compared with drug treatment for VT. The VTACH study, published in this week's edition of The Lancet, shows that use of catheter ablation prior to ICD implantation reduces the risk of VT recurrence at two years. The study is by Professor Karl-Heinz Kuck, Asklepios Klinik St Georg, Hamburg, Germany, and colleagues.

Patients who receive ICD shocks have a decreased quality of life (especially if five or more shocks per year are delivered) and increased compared with patients who do not receive shocks. Furthermore, ICDs do not prevent in 3𔃅% of patients. Drug treatment—especially amiodarone in combination with β blockers—can reduce the number of ICD interventions, but lifetime intake is necessary and it is associated with serious adverse events. The VTACH study was designed to assess prophylactic VT ablation followed by implantation of a cardioverter defibrillator in patients with previous heart attack, first episode of stable VT, and reduced left-ventricular function.

The randomised controlled trial was done in 16 centres in four European countries (Germany, Switzerland, Czech Republic, Denmark) and assessed 107 eligible patients aged 18—80 years: 52 were assigned to ablation plus ICD, and 55 to ICD only. Mean follow-up was 22.5 months. The researchers found that time to recurrence of VT or VF was longer in the ablation group (median 19 months) than in the control group (6 months). At two years, estimates for survival free from VT or VF were 47% in the ablation group and 29% in the control group—meaning that patients given ablation plus ICD were around 40% less likely to experience repeat VT or VF than those given ICD only. Complications related to the ablation procedure occurred in two patients; no deaths occurred within 30 days after ablation. A total of 15 device-related complications requiring surgical intervention occurred in 13 patients (ablation group, four; control group, nine). Nine patients died during the study (ablation group, five; control group, four).

The authors conclude: "Prophylactic VT ablation before defibrillator implantation seemed to prolong time to recurrence of VT in patients with stable VT, previous myocardial infarction, and reduced LVEF. Prophylactic should therefore be considered before implantation of a cardioverter defibrillator in such patients."

In an accompanying Comment, Dr William G Stevenson and Dr Usha Tedrow, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA, say: "Implantable defibrillators are a life-saving safety-net for patients with sustained ventricular tachycardia late after myocardial infarction. The VTACH trial suggests that ablation be considered early, in selected patients who are receiving an implantable cardioverter defibrillator for stable ventricular tachycardia, in whom recurrences of a ventricular tachycardia are likely. Evidence of a positive effect on survival, subsequent hospital admissions, or quality of life is needed before this strategy can be recommended for routine use. We believe that today's trial is further evidence to support early use of catheter ablation, as an alternative to antiarrhythmic drug therapy, for symptomatic recurrent ventricular tachycardia after implantation of an defibrillator, provided that the expertise to safely perform the procedure is available."

Explore further: AMA: Gender inequality still exists in medicine

add to favorites email to friend print save as pdf

Related Stories

Anger management: The key to staying heart healthy?

Feb 23, 2009

New research published in the March 3, 2009, issue of the Journal of the American College of Cardiology finds that anger-induced electrical changes in the heart can predict future arrhythmias in patients with implantable cardio ...

Recommended for you

New medical device to make the mines safer

Nov 21, 2014

Dehydration can be a serious health issue for Australia's mining industry, but a new product to be developed with input from Flinders University's Medical Device Partnering Program (MDPP) is set to more effectively ...

US family gets $6.75 million in Botox case

Nov 20, 2014

A New York couple who said Botox treatment of their son's cerebral palsy left him with life-threatening complications and sued its manufacturer won a $6.75 million verdict from a federal jury on Thursday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.