Study Finds Treatment With Anabolic Hormone May Enhance Local Bone Regeneration

Dec 22, 2009

(PhysOrg.com) -- In research that could open new avenues of investigation in the prevention and treatment of fractures, in bone regeneration and tissue engineering, scientists from Yale School of Medicine have found that a combination of bone marrow aspiration followed by treatment with anabolic parathyroid hormone (PTH) greatly boosted bone regeneration in localized areas in rats. The study appears online in the Journal of Bone and Mineral Research.

The Yale team removed marrow from the femurs of and treated the animals with PTH for three months. Earlier studies had shown that such treatment for three weeks produced robust but short-lived at the site of marrow removal. Over a three-month period, however, the researchers saw a 30 percent increase in .

According to lead author Agnčs Vignery, D.D.S, Ph.D., Associate Professor of Orthopaedics and Rehabilitation and Molecular and Cellular Biology at Yale, “This approach is simple and fast, and can lead to the formation of an amount of bone sufficient to prevent fractures in specific skeletal sites.”

The team further determined that filling the bone cavity with a bio-compatible calcium phosphate cement in rats treated with PTH over the same three month period also resulted in increased cortical thickness of the bone.

This aspect of the Yale research could have implications in the field of as calcium phosphate cements may provide a strong scaffold for new bone growth. “The marrow cavity offers a special niche to make new bone, which had not been explored to date,” Vignery said. “The use of bio-compatible calcium phosphate cement is an exciting and promising route to target the formation of new bone in lieu of bone marrow in skeletal sites that are at risk for fracture.”

Explore further: Human brain has coping mechanism for dehydration

add to favorites email to friend print save as pdf

Related Stories

Procedure developed at Yale creates new bone

Feb 14, 2008

A new technique that combines bone marrow removal and injection of a hormone helps promote rapid formation of new bone at targeted locations in the body, it was reported by Yale School of Medicine this month in Tissue En ...

Molecule dictates how stem cells travel

Jan 14, 2006

U.S. researchers have defined a molecule that dictates how blood stem cells travel to the bone marrow and establish blood and immune cell production.

Fossilized frogs yield bone marrow

Jul 27, 2006

Scientists say they've extracted bone marrow from fossilized frogs and salamanders that died 10 million years ago in the swamps of northeastern Spain.

Turning on adult stem cells may help repair bone

Jan 25, 2008

The use of a drug to activate stem cells that differentiate into bone appears to cause regeneration of bone tissue and be may be a potential treatment strategy for osteoporosis, according to a report in the February 2008 ...

Recommended for you

Stem cells from nerves form teeth

18 minutes ago

Researchers at Karolinska Institutet in Sweden have discovered that stem cells inside the soft tissues of the tooth come from an unexpected source, namely nerves. These findings are now being published in the journal Nature and co ...

Human brain has coping mechanism for dehydration

13 hours ago

(HealthDay)—Although dehydration significantly reduces blood flow to the brain, researchers in England have found that the brain compensates by increasing the amount of oxygen it extracts from the blood. ...

User comments : 0