Skull bone may hold the key to tackling osteoporosis

Dec 19, 2009

Scientists at Queen Mary, University of London have uncovered fundamental differences between the bone which makes up the skull and the bones in our limbs, which they believe could hold the key to tackling bone weakness and fractures.

It is well know that bones in the arms and legs become weak and vulnerable to breaks when they are not maintained by weight bearing exercise. However , which bears almost no weight remains particularly resistant to breaking.

The new research published in PLoS ONE offers an explanation for this phenomenon for the first time. The researchers say that their new understanding of the differences between the two types of bone could lead to new ways to treat or prevent .

People who develop osteoporosis have fragile bones which are prone to breaking. The condition becomes more common as we age, especially in post-menopausal women when levels of oestrogen fall dramatically. In the over 50s it affects half of all women and a fifth of all men.

The researchers wanted to understand why the skull bones are resistant to bone thinning as they age, even in post-menopausal women.

To investigate this, they looked in detail at rat from the and compared them with cells from limb bone. They found differences between the appearance of the cells and how they behaved in the lab. They also noticed that treating the cells with oestrogen had a far greater effect on the cells from the limb bone.

Because the differences are so profound, the researchers believe that they are set very early on in life - probably when the bones are still forming in the womb.

The researchers also made a detailed genetic study of the two types of bone cell. They looked at which were active in the two types of cell and found a startling level of difference between the two. The found a total of 1236 - around four per cent of the - were showing different levels of activity in the two types of bone cell.

Among these they found a number of genes which are known to be involved in the process of forming healthy bones.

Lead author, Dr Simon Rawlinson, Lecturer in Oral Biology at Queen Mary, University of London, explained: "This research is exciting because it tells us why our skulls remain so tough as we age compared to the bones in our arms and legs.

"Now we understand this phenomenon better, we also understand osteoporosis better. And this has opened up many new lines of research into how the disease could be treated or even prevented."

Explore further: Artificial sweeteners linked to abnormal glucose metabolism

add to favorites email to friend print save as pdf

Related Stories

Smashing the time it takes to repair our bones

Dec 04, 2006

New research by Queensland University of Technology is helping scientists better understand how bone cells work and may one day lead to the development of technology that can speed up the time it takes to heal fractured and ...

Sticks and stones break bones, but new study may prevent it

Dec 09, 2009

The best way to prevent a fracture is to stop bones from reaching the point where they are prone to breaking, but understanding the process of how bones form and mature has been challenging. Now researchers at the University ...

Recommended for you

Connection found between birth size and brain disorders

15 hours ago

(Medical Xpress)—A trio of researchers has found what appears to be a clear connection between birth size and weight, and the two brain disorders, autism and schizophrenia. In their paper published in Proceedings of ...

A novel therapy for sepsis?

Sep 16, 2014

A University of Tokyo research group has discovered that pentatraxin 3 (PTX3), a protein that helps the innate immune system target invaders such as bacteria and viruses, can reduce mortality of mice suffering ...

User comments : 0