Childhood cancer survivor study report: Late recurrence is a risk for some cancers

Dec 04, 2009

Late recurrence is a risk for some pediatric cancers, particularly Ewing sarcomas and tumors of the central nervous system, according to a new study published online December 4 in the Journal of the National Cancer Institute.

This study was undertaken because there is limited research on late recurrence (after 5 years and up to 20 years) for pediatric cancer patients.

Karen Wasilewski-Masker, M.D., of the Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Scottish Rite, and colleagues analyzed data from the Survivor Study for 12,795 five-year survivors of the most common pediatric cancers. Cumulative incidence of late recurrence at 5, 10, 15, and 20 years after diagnosis was calculated using death as a competing risk.

The overall pediatric cancer recurrence rate was 4.4% at 10 years and 6.2% at 20 years among 5-year survivors. Thirteen percent of Ewing sarcomas and 14.4% of astrocytomas had recurred by 20 years. Only 0.9% of pediatric kidney tumors, 2.4% of Non-Hodgkin lymphomas, and 2.6% of neuroblastomas had recurred in 5 year-survivors by 20 years after treatment.

"Future research is needed to determine the risk of recurrence in subgroups of survivors and the cost-effectiveness of long-term disease surveillance in at-risk patient groups because these factors need to be considered in long-term follow-up and transitional care plans," the authors write.

Source: Journal of the National Institute (news : web)

Explore further: Solving cancer's secrets

add to favorites email to friend print save as pdf

Related Stories

U of MN study finds children with leukemia are living longer

Dec 11, 2006

More than 90 percent of children and young adults who survive five years or longer after diagnosis and treatment for acute myeloid leukemia (AML) are alive 20 years later and leading productive lives, according to a University ...

Recommended for you

Solving cancer's secrets

37 minutes ago

Some fathers play ball with their sons. Or take them fishing. Chuck Perou's father took his son to his pathology lab to show him how a pathologist conducts tests and runs experiments. Perou, a nature junky ...

Cancer stem cells linked to drug resistance

20 hours ago

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered ...

User comments : 0

More news stories

Scientists make critical end-stage liver discovery

(Medical Xpress)—A team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse ...

Solving cancer's secrets

Some fathers play ball with their sons. Or take them fishing. Chuck Perou's father took his son to his pathology lab to show him how a pathologist conducts tests and runs experiments. Perou, a nature junky ...

Harm-reduction program optimizes HIV/AIDS prevention

(Medical Xpress)—New research from UC San Francisco and the San Francisco AIDS Foundation has found that clients participating in a harm-reduction substance use treatment program, the Stonewall Project, decrease their use ...

Meth mouth menace

Something was up in Idaho. While visiting a friend in Athol, a small town north of Coeur d'Alene, Jennifer Towers, director of research affairs at the Tufts University School of Dental Medicine, noticed ...