Why Some Monkeys Don't Get AIDS

Dec 03, 2009
Why Some Monkeys Don't Get AIDS
Sooty Mangabeys

(PhysOrg.com) -- Two studies published this month in the Journal of Clinical Investigation provide a significant advance in understanding how some species of monkeys such as sooty mangabeys and African green monkeys avoid AIDS when infected with SIV, the simian equivalent of HIV.

Using comparative genomics of SIV infection, researchers at the University of Pennsylvania School of Medicine, with collaborators from University of Minnesota, the University of Toronto, and Emory University, looked at sooty mangabeys, and a second group at the Pasteur Institute in France, looked at African green monkeys to identify possible genes related to disease progression or resistance.

“Sooty mangabeys are able to rapidly shut down the immune response after the initial SIV infection, and remain healthy. The mangabeys respond to SIV in a manner similar to rhesus macaques, which get sick, or to humans infected with , but the mangabeys do not get sick,” says first author Steven E. Bosinger, PhD , a postdoctoral fellow in the Department of Pathology and Laboratory Medicine.

“The Penn study is a step forward in understanding why some African monkeys do not get sick when they are infected with SIV, which is a key question in contemporary research,” says senior author Guido Silvestri, MD, associate professor of Pathology and Laboratory Medicine and Director of Clinical Virology.

The Penn study compared changes induced by SIV infection on the overall profile of gene expression in two species of : rhesus macaques, which undergo an AIDS-like disease when infected with SIV, and sooty mangabeys, which, in stark contrast, remain AIDS-free despite life-long infection. Sooty mangabeys, which are native to Western Africa and infected naturally in the wild, were previously believed by some to remain asymptomatic because of a genetic inability to mount innate immune responses to SIV, and in particular, to produce type I interferons.

However, the current studies change the way AIDS researchers think about human versus simian AIDS infection. The sooty mangabeys' robust antiviral immune response upon SIV infection, including a massive up-regulation of interferon response genes, or ISGs, indicates production of type I interferons in the mangabeys. Of note, this antiviral response is transient, as seen in sooty mangabeys, lasting for about four weeks, but remains constant over time in rhesus macaques, which may contribute to the immunodeficiency seen in this species. SIV induces a massive activation of immune molecules in both species, but only sooty mangabeys are able to bring the response under control.

In addition, by comparing the changes induced by infection on the overall profile of of rhesus macaques versus sooty mangabeys, the research teams identified genes whose expression may be responsible for disease progression or, alternatively, disease resistance. These genes may provide novel targets for AIDS therapy.

Provided by University of Pennsylvania School of Medicine (news : web)

Explore further: Condoms 'too small' for Uganda men

add to favorites email to friend print save as pdf

Related Stories

Ancestor of HIV in primates may be surprisingly young

May 01, 2009

The ancestors of the simian immunodeficiency viruses (SIVs) that jumped from chimpanzees and monkeys, and ignited the HIV/AIDS pandemic in humans, have been dated to just a few centuries ago. These ages are substantially ...

AIDS resistance secret may be in blood

Feb 12, 2007

U.S. scientists say the absence of a specific marker in the blood and tissues of certain monkeys might be part of the key to understanding AIDS resistance.

Novel vaccine approach offers hope in fight against HIV

May 17, 2009

A research team may have broken the stubborn impasse that has frustrated the invention of an effective HIV vaccine, by using an approach that bypasses the usual path followed by vaccine developers. By using ...

Recommended for you

Obese British man in court fight for surgery

Jul 11, 2011

A British man weighing 22 stone (139 kilograms, 306 pounds) launched a court appeal Monday against a decision to refuse him state-funded obesity surgery because he is not fat enough.

2008 crisis spurred rise in suicides in Europe

Jul 08, 2011

The financial crisis that began to hit Europe in mid-2008 reversed a steady, years-long fall in suicides among people of working age, according to a letter published on Friday by The Lancet.

New food labels dished up to keep Europe healthy

Jul 06, 2011

A groundbreaking deal on compulsory new food labels Wednesday is set to give Europeans clear information on the nutritional and energy content of products, as well as country of origin.

Overweight men have poorer sperm count

Jul 04, 2011

Overweight or obese men, like their female counterparts, have a lower chance of becoming a parent, according to a comparison of sperm quality presented at a European fertility meeting Monday.

User comments : 0