Gene implicated in stress-induced high blood pressure

Nov 23, 2009

Do stressful situations make your blood pressure rise? If so, your phosducin gene could be to blame according to a team of researchers, at the University of Freiburg, Germany, and the Medical College of Wisconsin, Milwaukee, that has identified a role for the protein generated by the phosducin gene in modulating blood pressure in response to stress in both mice and humans.

The team, led by Lutz Hein and Ulrich Broeckel, generated lacking phosducin and found that they had increased baseline when compared with normal mice and that they showed enhanced increases in blood pressure in response to post-operative stress. Analysis in humans indicated that a number of phosducin gene variants were associated with certain stress-dependent blood pressure responses. Further, one in particular was associated with elevated baseline blood pressure.

These data led the authors to suggest that phosducin might be a good target for drugs designed to alleviate stress-induced high blood pressure. In an accompanying commentary, however, Guido Grassi, at Clinica Medica, Italy, notes that further studies are needed before the therapeutic implications of these data can really be determined.

More information: Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. View this article at: www.jci.org/articles/view/38433?key=ch6PLgvm06ENhpLnhy41

Source: Journal of Clinical Investigation

Explore further: Key milestone for brown fat research with a ground-breaking MRI scan

add to favorites email to friend print save as pdf

Related Stories

Elderly may have higher blood pressure in cold weather

Jan 12, 2009

Outdoor temperature and blood pressure appear to be correlated in the elderly, with higher rates of hypertension in cooler months, according to a report in the January 12 issue of Archives of Internal Medicine.

Genes and drugs team up to lower blood pressure

Sep 13, 2007

Patients with high blood pressure respond very differently to antihypertensive medication, making treatment selection tricky for physicians. But new research published in the online open access journal, BMC Medical Genetics, pinpoi ...

Recommended for you

Gate for bacterial toxins found

9 hours ago

Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the Institute of Experimental and Clinical Pharmacology and Toxicology of the University of Freiburg have discovered the receptor responsible ...

User comments : 0

More news stories

Down's chromosome cause genome-wide disruption

The extra copy of Chromosome 21 that causes Down's syndrome throws a spanner into the workings of all the other chromosomes as well, said a study published Wednesday that surprised its authors.

Progress in the fight against quantum dissipation

(Phys.org) —Scientists at Yale have confirmed a 50-year-old, previously untested theoretical prediction in physics and improved the energy storage time of a quantum switch by several orders of magnitude. ...

Meteorites yield clues to Martian early atmosphere

(Phys.org) —Geologists who analyzed 40 meteorites that fell to Earth from Mars unlocked secrets of the Martian atmosphere hidden in the chemical signatures of these ancient rocks. Their study, published ...