Medication improves health of patients with pulmonary arterial hypertension

Nov 17, 2009

In one of the few studies of the long-term effects of medication in the treatment of pulmonary arterial hypertension (PAH) disease, a team of researchers found the health and exercise capacity of PAH patients improved after two years of treatment with ambrisentan, according to a study published in the current edition of the Journal of the American College of Cardiology.

A research team led by Ronald Oudiz, MD, FACC, a principal investigator at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), conducted a follow-up of the studies conducted for the Food and Drug Administration's approval of ambrisentan. The researchers found 383 PAH patients treated for two years with ambrisentan had sustained improvements in their . The team also found a low risk of death and clinical worsening from the disease among the PAH patients treated with ambrisentan for two years.

"These are promising findings for patients who suffer from , an often fatal disease of the pulmonary circulation," said Dr. Oudiz. "Physicians and patients with PAH should consider the use of ambrisentan as part of a long-term strategy for treatment of the disease."

PAH is a disease of the pulmonary circulation often afflicting younger women and is characterized by a progressive elevation in pulmonary vascular resistance that leads to right ventricular failure and . Although the number of approved therapies for PAH has grown in the past 10 years, the disease remains rapidly progressive with a poor prognosis for most patients. Despite treatment, 25% to 50% of all patients with PAH will not survive beyond five years.

Ambrisentan is an orally active, once-daily medication currently approved for the treatment of PAH patients in the U.S. and other countries on the basis of two 12-week randomized, double-blind, placebo-controlled, multicenter efficacy trials. In these studies, the drug improved exercise capacity, along with other clinical indications of PAH disease severity, including clinical worsening.

Prior to their study, the researchers said most long-term PAH studies have focused primarily on exercise capacity and safety for up to one year, with very little description of clinical effectiveness of ambrisentan .

The researchers in the current two-year study found that the two higher doses of the medication, 5 milligrams and 10 milligrams, provided a sustained benefit. The lower dosage used in the study, 2.5 milligrams, was less effective, the researchers said.

Source: UCLA Medical Center

Explore further: Recorded Ebola deaths top 7,000

add to favorites email to friend print save as pdf

Related Stories

A type of antioxidant may not be as safe as once thought

Sep 04, 2007

Certain preparations taken to enhance athletic performance or stave off disease contain an anti-oxidant that could cause harm. According to new research at the University of Virginia Health System, N-acetylcysteine (NAC), ...

Mars Rover device gets new mission on Earth

Feb 05, 2009

Developed to sniff out extraterrestrial life on other planets, a portable device known as the Mars Organic Analyzer (MOA) is taking on a new role in detecting air pollutants on Earth. Researchers in California ...

Endothelin drugs benefit those with pulmonary hypertension

Sep 10, 2009

Recent research to block the effects of endothelin, a powerful substance that constricts blood vessels and stimulates cell growth, has led to successful treatment of pulmonary arterial hypertension and provides hope for treating ...

Recommended for you

Recorded Ebola deaths top 7,000

3 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

8 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.