New cause of osteoporosis: Mutation in a miroRNA

Nov 16, 2009

Many biological processes are controlled by small molecules known as microRNAs, which work by suppressing the expression of specific sets of genes. Xiang-Hang Luo and colleagues, at Second Xiangya Hospital of Central South University, People's Republic of China, have now identified a previously unknown microRNA (miR-2861) as crucial to bone maintenance in mice and humans. Of clinical importance, expression of functional miR-2861 was absent in two related adolescents with primary osteoporosis.

Several lines of evidence determined the key role of miR-2861 in maintaining bone. First, miR-2861 promoted the in vitro development of a mouse stromal cell line into the cells responsible for .

Second, in mice, in vivo silencing of miR-2861 inhibited bone formation and decreased bone mass. Last, analysis of ten patients with primary revealed two related adolescents in whom disease was caused by a mutation in the miR-2861 precursor (pre-miR-2861) that blocked expression of miR-2861. These data led the authors to conclude that miR-2861 has an important role in controlling the generation of the cells responsible for bone formation and that defects in the processing of its precursor can cause osteoporosis.

More information: A novel microRNA targeting HDAC5 regulates osteoblast differentiation in and contributes to primary osteoporosis in humans, view this article at: http://www.jci.org/articles/view/39832?key=wTvdY50uyZkh8Uji59Po

Source: Journal of Clinical Investigation

Explore further: Using mathematical theory and software tools, team studies why a variable heart rate is a sign of health and fitness

add to favorites email to friend print save as pdf

Related Stories

MicroRNA controls expression of oncogenes

Jun 09, 2008

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press ...

Two microRNAs promote spread of tumor cells

Jan 28, 2008

The more scientists learn about microRNAs – short strands of RNA that can interfere with normal gene activity – the more obvious it becomes how closely they are associated with cancer. In a new study, scientists at The ...

Recommended for you

A better way to track emerging cell therapies using MRIs

Sep 19, 2014

Cellular therapeutics – using intact cells to treat and cure disease – is a hugely promising new approach in medicine but it is hindered by the inability of doctors and scientists to effectively track the movements, destination ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

PPihkala
not rated yet Nov 16, 2009
Somebody should correct the subject of this article (miroDNA -> microDNA)