Inappropriate sepsis therapy leads to fivefold reduction in survival

Nov 05, 2009

Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the cases of 5,715 patients with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical infection site, and relevant pathogens.

Results showed that inappropriate initial antimicrobial therapy occurred in 20 percent of patients, and the overall was 43.7 percent. Survival after appropriate and inappropriate initial therapy was 52 percent and 10.3 percent, respectively.

Furthermore, the decrease in survival with inappropriate initial therapy ranged from 2.3-fold for pneumococcal infection to 17.6-fold with primary bacteremia. Researchers conclude that efforts to increase the frequency of appropriateness of initial antimicrobial therapy must be central to efforts to reduce from .

The article is published in the November issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.

Source: American College of Chest Physicians

Explore further: Reducing kidney injury using a quality improvement method

add to favorites email to friend print save as pdf

Related Stories

Recommended treatment for heart failure often underused

Oct 20, 2009

Less than one-third of patients hospitalized for heart failure and participating in a quality improvement registry received a guideline-recommended treatment of heart failure, aldosterone antagonist therapy, according to ...

The balance shifts

May 27, 2008

The risk of contracting a Clostridium difficile infection following operations for which a "prophylactic" antibiotic is given to prevent infection is 21 times greater now than it was just a decade ago, according to researchers ...

Prostate cancer vaccines more effective with hormone therapy

Jul 10, 2008

Among patients with castration-resistant prostate cancer, the addition of hormone therapy following vaccine treatment improved overall survival compared with either treatment alone or when the vaccine followed hormone treatment, ...

Recommended for you

Reducing kidney injury using a quality improvement method

3 hours ago

Using quality improvement measures in eight of the 10 hospitals in the Northern New England Cardiovascular Disease Study Group, researchers have found a way to reduce kidney injury in patients undergoing a procedure with ...

App for headache sufferers shows success

15 hours ago

A unique app that helps headache sufferers to record the severity and regularity of their pain is being used as part of a Griffith research study.

West African airline suspends flights amid Ebola (Update)

21 hours ago

(AP)—Police officers deployed to Liberia's international airport to ensure passengers are screened for Ebola symptoms as a major regional airline announced Tuesday it was suspending flights to the cities hardest hit by ...

User comments : 0