Pregnant women risk early delivery from using psychiatric medication

Oct 29, 2009 by Joel Schwarz

(PhysOrg.com) -- Women with a history of depression who used psychiatric medicine during pregnancy have triple the odds of delivering a premature baby.

The odds triple for premature child delivery pregnant with a history of depression who used psychiatric medication, according to a new study.

Researchers at the University of Washington, University of Michigan and Michigan State University found that a combination of medication use and depression -- either before or during -- was strongly linked to delivery before 35 weeks' gestation.

Amelia Gavin, lead author and UW assistant professor of social work, said the findings highlight the need for carefully planned studies that can clarify associations between depression, psychiatric medications and preterm delivery.

"Women with depression face difficult decisions regarding the benefits and risks of using psychotropic medications in pregnancy," Gavin said. "Therefore, a focus on disentangling medication effects and depression effects on mother and offspring health should be a major clinical priority."

"Medication use may be an indicator of depressive symptom severity, which is a direct or indirect contributing factor to pre-term delivery," added Kristine Siefert, co-author and a Michigan professor of social work.

Most physicians initiated preterm deliveries after the women suffered complications, such as pre-eclampsia, poor fetal growth or acute hemorrhage.

The study examined the associations among maternal depression, psychiatric medication use in pregnancy and preterm delivery among women in five Michigan communities who received prenatal care at one of 52 participating clinics between September 1998 and June 2004These women had to be at least 15 years old, with no history of diabetes, and were 15 to 27 weeks pregnant.

Researchers analyzed responses of nearly 3,020 women who participated in the Michigan-based Pregnancy Outcomes and Community Health Study, which asked about depressive symptoms that occurred within the week of taking the questionnaire. The study also asked about the women's history of depression that required medication, such as tranquilizers or sleeping pills.

Overall, 335 women (11 percent) delivered preterm. Among the women who reported having depression during pregnancy, 75 percent had a history of depression and 62 percent used medication in the first half of pregnancy.

Another finding showed that without medication use, elevated levels of depressive symptoms at midpregnancy and history of did not pose an increased risk of .

The study's other researchers include Claudia Holzman, professor of epidemiology at Michigan State, and Yan Tian, a data analyst at Michigan State.

The findings appear in the September/October issue of Women's Health Issues.

Provided by University of Washington (news : web)

Explore further: Rising role seen for health education specialists

add to favorites email to friend print save as pdf

Related Stories

Pregnancy hormone predicts postpartum depression

Feb 02, 2009

Women who have higher levels of a hormone produced by the placenta midway through pregnancy appear more likely to develop postpartum depression, a study authored by a UC Irvine researcher finds.

Treating Depression in Pregnancy

Sep 21, 2009

A new report from the American Psychiatric Association (APA) and the American College of Obstetricians and Gynecologists, which is published by Elsevier in the September-October 2009 issue of General Hospital Psychiatry, explores ...

Recommended for you

Rising role seen for health education specialists

59 minutes ago

(HealthDay)—A health education specialist can help family practices implement quality improvement projects with limited additional financial resources, according to an article published in the March/April ...

FDA proposes first regulations for e-cigarettes

1 hour ago

The federal government wants to prohibit sales of electronic cigarettes to minors and require approval for new products and health warning labels under regulations being proposed by the Food and Drug Administration.

Vermont moves toward labeling of GMO foods

1 hour ago

Vermont lawmakers have passed the country's first state bill to require the labeling of genetically modified foods as such, setting up a war between the behemoth U.S. food industry and an American public that overwhelmingly ...

User comments : 0

More news stories

Rising role seen for health education specialists

(HealthDay)—A health education specialist can help family practices implement quality improvement projects with limited additional financial resources, according to an article published in the March/April ...

FDA proposes first regulations for e-cigarettes

The federal government wants to prohibit sales of electronic cigarettes to minors and require approval for new products and health warning labels under regulations being proposed by the Food and Drug Administration.

When things get glassy, molecules go fractal

Colorful church windows, beads on a necklace and many of our favorite plastics share something in common—they all belong to a state of matter known as glasses. School children learn the difference between ...

FCC to propose pay-for-priority Internet standards

The Federal Communications Commission is set to propose new open Internet rules that would allow content companies to pay for faster delivery over the so-called "last mile" connection to people's homes.

SK Hynix posts Q1 surge in net profit

South Korea's SK Hynix Inc said Thursday its first-quarter net profit surged nearly 350 percent from the previous year on a spike in sales of PC memory chips.

Brazil enacts Internet 'Bill of Rights'

Brazil's president signed into law on Wednesday a "Bill of Rights" for the digital age that aims to protect online privacy and promote the Internet as a public utility by barring telecommunications companies ...