Cholesterol-lowering medicines may be effective against cancer

Oct 27, 2009
This is C. elegans, the nematode that Marc Pilon and his colleagues used in the study. Credit: Marc Pilon

Millions of people around the world use medicines based on statins to lower their blood cholesterol, but new research from the University of Gothenburg, published in the prestigious journal PNAS, shows that statins may also be effective in the treatment of cancer.

Statins lower by blocking certain enzymes involved in our metabolism. However, they have also been shown to affect other important lipids in the body, such as the lipids that help proteins to attach to the cell membrane (known as modification). Because many of the proteins that are lipid-modified cause , there are now hopes that it will be possible to use statins in the treatment of cancer.

It is, however, very difficult to study the side-effects of statins in mammals. As a first step, Marc Pilon, researcher at the Department of Cell and Molecular Biology at the University of Gothenburg, has teamed up with Swedish and international colleagues to carry out studies on the nematode C. elegans. This nematode, which is made up of just a thousand or so cells, does not produce cholesterol and is therefore an ideal test subject.

The Gothenburg researchers' studies show that statins can have a dramatic inhibitory effect on growth and development. As the researchers managed to identify the enzyme involved, they can also explain how the effect arises at molecular level.

"Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of and neurological disorders such as Parkinson's."

Source: University of Gothenburg (news : web)

Explore further: Study finds enzyme inhibitors suppress herpes simplex virus replication

add to favorites email to friend print save as pdf

Related Stories

Statins lower stroke severity, improve recovery

Feb 26, 2009

Mayo Clinic researchers have shown that patients who were taking statins before a stroke experienced better outcomes and recovery than patients who weren't on the drug — even when their cholesterol levels were ideal. The ...

Recommended for you

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.