Novel findings shed light on how N-type channel function is modified by lipids

Oct 26, 2009

The November 2009 issue of the Journal of General Physiology (JGP) contains two papers by the Rittenhouse laboratory that describe novel findings on how N-type voltage-gated calcium channel (VGCC) function is modified by lipids.

In a commentary accompanying the manuscripts, Jörg Striessnig (University of Innsbruck) provides context for the importance of the new Rittenhouse studies, which support one of two distinct hypotheses on modulation of VGCCs that have been pitted in an "oily competition": the "PIP2 breakdown" vs. "ArA generation" hypotheses.

According to Striessnig, although the new findings support the "ArA generation" hypothesis, previous experimental evidence supporting the "PIP2 breakdown" model are valid, and he proposes a unifying hypothesis that could serve as a basis for further experiments.

More information:

• Heneghan, J.F., et al. 2009. J. Gen. Physiol. doi:10.1085/jgp.2009102doi:10doi:10.1085/jgp.200910330Ganguli, T., et al. 2009. J. Gen. Physiol. doi:10.1085/jgp.200910204
• Striessnig, J. J. Gen. Physiol. doi:10.1085/jgp.200910330

Source: Rockefeller University (news : web)

Explore further: New compounds protect nervous system from the structural damage of MS

add to favorites email to friend print save as pdf

Related Stories

Teasing apart T helper cells

Jul 27, 2009

The cytokine IL-9 promotes a multiple sclerosis-like disease in mice, according to a new study by Nowak et al. published online on July 13th in the Journal of Experimental Medicine. In a related Commentary, Richar ...

Researchers reveal mechanism for neuron self-preservation

Oct 19, 2009

Tsuruta et al. find that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. The study appears in the October 19, 2009 issue of the Journal of ...

Recommended for you

Mystery of the reverse-wired eyeball solved

Feb 27, 2015

From a practical standpoint, the wiring of the human eye - a product of our evolutionary baggage - doesn't make a lot of sense. In vertebrates, photoreceptors are located behind the neurons in the back of the eye - resulting ...

Neurons controlling appetite made from skin cells

Feb 27, 2015

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight ...

Quality control for adult stem cell treatment

Feb 27, 2015

A team of European researchers has devised a strategy to ensure that adult epidermal stem cells are safe before they are used as treatments for patients. The approach involves a clonal strategy where stem cells are collected ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.