Novel findings shed light on how N-type channel function is modified by lipids

Oct 26, 2009

The November 2009 issue of the Journal of General Physiology (JGP) contains two papers by the Rittenhouse laboratory that describe novel findings on how N-type voltage-gated calcium channel (VGCC) function is modified by lipids.

In a commentary accompanying the manuscripts, Jörg Striessnig (University of Innsbruck) provides context for the importance of the new Rittenhouse studies, which support one of two distinct hypotheses on modulation of VGCCs that have been pitted in an "oily competition": the "PIP2 breakdown" vs. "ArA generation" hypotheses.

According to Striessnig, although the new findings support the "ArA generation" hypothesis, previous experimental evidence supporting the "PIP2 breakdown" model are valid, and he proposes a unifying hypothesis that could serve as a basis for further experiments.

More information:

• Heneghan, J.F., et al. 2009. J. Gen. Physiol. doi:10.1085/jgp.2009102doi:10doi:10.1085/jgp.200910330Ganguli, T., et al. 2009. J. Gen. Physiol. doi:10.1085/jgp.200910204
• Striessnig, J. J. Gen. Physiol. doi:10.1085/jgp.200910330

Source: Rockefeller University (news : web)

Explore further: Scientists discover new clues to how weight loss is regulated

add to favorites email to friend print save as pdf

Related Stories

Teasing apart T helper cells

Jul 27, 2009

The cytokine IL-9 promotes a multiple sclerosis-like disease in mice, according to a new study by Nowak et al. published online on July 13th in the Journal of Experimental Medicine. In a related Commentary, Richar ...

Researchers reveal mechanism for neuron self-preservation

Oct 19, 2009

Tsuruta et al. find that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. The study appears in the October 19, 2009 issue of the Journal of ...

Recommended for you

Team finds key signaling pathway in cause of preeclampsia

16 hours ago

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause ...

Rapid test to diagnose severe sepsis

20 hours ago

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.

User comments : 0