Blood test shows promise for early diagnosis of Alzheimer's disease

Oct 21, 2009

Elderly people exhibiting memory disturbances that do not affect their normal, daily life suffer from a condition called "mild cognitive impairment" (MCI). Some MCI patients go on to develop Alzheimer's disease within a few years, whereas other cases remain stable, exhibiting only benign senile forgetfulness. It is crucial to develop simple, blood-based tests enabling early identification of these patients that will progress in order to begin therapy as soon as possible, potentially delaying the onset of dementia.

A group of investigators, led by Professor Massimo Tabaton of the University of Genoa, Italy, have data that sheds light on this issue. The results of their research are published in the October issue of the Journal of Alzheimer's Disease.

The investigators report that the concentration in blood of amyloid beta "42," the toxic molecule that is believed to be the main cause of Alzheimer's disease, is, on average, higher in MCI cases that went on to develop Alzheimer's disease approximately three years later. The values of amyloid beta in blood vary considerably among the patient groups examined (MCI that develop ; MCI stable; normal subjects).

"This variability is likely very important," Dr. Tabaton noted and went on to add, "but means that this needs further work before we can use this test for a definitive diagnosis." For example, the scientists are going to set up a test that picks up a variant of amyloid beta potentially more specific of the disease.

More information: Cammarata, Sergio, Roberta Borghi, Luca Giliberto, Matteo Pardini, Valeria Pollero, Cristina Novello, Michele Fornaro, Antonella Vitali, Laura Bracco, Carlo Caltagirone, Paola Bossů, Patrizio Odetti and Massimo Tabaton. Amyloid-β_{42} Plasma Levels are Elevated in Amnestic . J Alzheimers Dis 18:2 (October 2009).

Source: IOS Press (news : web)

Explore further: Hong Kong raises bird flu alert level as woman critical

add to favorites email to friend print save as pdf

Related Stories

MRI shows brain atrophy pattern that predicts Alzheimer's

Feb 10, 2009

Using special MRI methods, researchers have identified a pattern of regional brain atrophy in patients with mild cognitive impairment (MCI) that indicates a greater likelihood of progression to Alzheimer's disease. The findings ...

New technique opens door to early Alzheimer's diagnosis

Jun 16, 2009

A new diagnostic technique which may greatly simplify the detection of Alzheimer's disease has been discovered by researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal's ...

Recommended for you

Four die of bird flu in Libya: minister

7 hours ago

Four people have died of bird flu in Libya in recent days, the health minister of the country's internationally recognised government said on Saturday.

Ebola expert calls for European anti-virus 'corps'

Dec 26, 2014

Europe will be "vulnerable" if it does not regard viruses as a "national security issue" like the United States, the microbiologist who discovered Ebola said in an interview published Friday.

In Liberia, Ebola steals Christmas

Dec 26, 2014

The Ebola epidemic has cast a dark shadow over Christmas this year in Liberia, where small businesses are especially feeling the pinch.

Firm recalls caramel apples amid listeria fears

Dec 25, 2014

A Missouri firm is recalling its Happy Apple brand caramel apples because of the potential that they could be contaminated with listeria. The recall comes after at least three deaths and at least 29 illnesses in 10 states ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.