Aggressive microdermabrasion induces wound-healing response in aging skin

Oct 19, 2009

Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process, according to a report in the October issue of Archives of Dermatology, one of the JAMA/Archives journals.

"Microdermabrasion is a popular procedure for skin rejuvenation," the authors write as background information in the article. "It has been suggested that microdermabrasion can improve the appearance of wrinkles, atrophic acne scars, dyspigmentation and other signs of aging skin." The procedure involves buffing the skin using grains of diamond or another hard substance. In order to objectively change the appearance of wrinkled skin, such a procedure would have to induce the production of collagen, the major structural protein in the skin. Previous studies have shown that microdermabrasion using may not always stimulate collagen production; whether more aggressive but still nonablative (not involving the destruction of skin tissue) methods could consistently do so is unknown.

Darius J. Karimipour, M.D., and colleagues at the University of Michigan, Ann Arbor, conducted a of skin biopsy specimens before and four hours to 14 days after a microdermabrasion procedure. Forty adults age 50 to 83 years with sun-damaged skin on their arms volunteered to participate in the study. Each underwent microdermabrasion with a diamond-studded handpiece of either a coarse-grit or medium-grit abrasiveness.

When performed with the coarse-grit handpiece, microdermabrasion resulted in the increased production of a wide variety of compounds associated with and skin remodeling. This includes cytokeratin 16, a well-characterized response to injuries to the skin's outer layer; antimicrobial peptides that fight infection; that break down skin's structural proteins to allow for rebuilding; and both collagen precursors and other substances that form the pathway to its production.

These molecular changes were not seen in individuals who received microdermabrasion using the medium-grit handpiece, the authors note. All patients experienced a mild period of redness that typically lasted less than two hours.

"We demonstrate that aggressive nonablative microdermabrasion is an effective procedure to stimulate collagen production in human skin in vivo," they write. "The beneficial molecular responses, with minimal downtime, suggest that aggressive microdermabrasion may be a useful procedure to stimulate remodeling and to improve the appearance of aged human ."

More information: Arch Dermatol. 2009;145[10]:1114-1122.

Source: JAMA and Archives Journals (news : web)

Explore further: Startup commercializing innovation to reduce neurotoxin that damages nerve cells, triggers pain

add to favorites email to friend print save as pdf

Related Stories

Light-activated therapy may change skin at molecular level

Oct 20, 2008

Photodynamic therapy—which involves a light-activated medication and exposure to a light source—appears to produce changes at the molecular level in aging skin, according to a report in the October issue of Archives of ...

Sun-damaged skin does not improve with estrogen treatments

Sep 15, 2008

Treating the skin with estrogen can stimulate collagen production—which improves the appearance of the skin—in areas not typically exposed to the sun, according to new research from the University of Michigan Health System.

Another new wrinkle in treating skin aging

Jun 05, 2008

Topical applications of a naturally occurring fat molecule have the potential to slow down skin aging, whether through natural causes or damage, researchers report.

Recommended for you

Cellular protein may be key to longevity

23 hours ago

Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions ...

Gut bacteria tire out T cells

Sep 15, 2014

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Me ...

T-bet tackles hepatitis

Sep 15, 2014

A single protein may tip the balance between ridding the body of a dangerous virus and enduring life-long chronic infection, according to a report appearing in The Journal of Experimental Medicine.

User comments : 0