Effects of aspirin and folic acid on inflammation markers for colorectal adenomas

Oct 12, 2009

Unexpectedly, inflammation markers do not appear to be involved with the chemopreventative effect of aspirin on colorectal adenomas, according to a brief communication published online October 12 in the Journal of the National Cancer Institute.

Aspirin has been shown to prevent the recurrence of colorectal polyps, but it's not clear how it works. One hypothesis is that it may affect the levels of substances, such as C-reactive protein and others, that are markers of inflammation.

To study this, Gloria Y.F. Ho, Ph.D., of the department of Epidemiology & Population Health, at Albert Einstein College of Medicine in Bronx, N.Y., and colleagues examined changes in plasma levels of five inflammation markers—C-reactive protein, interleukin 6, tumor necrosis factor, soluble TNF receptor type II, and IL-1 receptor antagonist—at baseline and at year 3 of 884 subjects. The trial had three groups (including an aspirin group) and two folic acid groups (including a folate placebo group).

Changes in levels of all five inflammation markers were not associated with adenoma recurrence. For those who did not receive folic acid, C-reactive protein levels in those in the 325 mg/d aspirin group changed very little, whereas it was statistically significantly increased in the placebo group. For subjects who received folic acid, the reverse association was observed.

"Our data suggest that low dose aspirin has modest effects on stabilizing [C-reactive protein], which may be abrogated by a high level of folate," the authors write. "However, such beneficial effects do not appear to confer protection against colorectal neoplasia. Inflammation markers do not mediate the previously observed effects of aspirin and folic acid on colorectal adenomas."

Source: (news : web)

Explore further: Target growth-driving cells within tumors, not fastest-proliferating cells

add to favorites email to friend print save as pdf

Related Stories

Aspirin shows promise for colon cancer patients

Aug 11, 2009

Men and women who were diagnosed with colorectal cancer and began regular use of aspirin had a lower risk of overall and colorectal cancer death compared to patients not using aspirin, according to a study in the August 12 ...

Recommended for you

Same cancer, different time zone

9 hours ago

Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome.

Brazilian researchers identify RNA that regulates cell death

13 hours ago

Researchers from the University of São Paulo (USP) have identified an RNA known as INXS that, although containing no instructions for the production of a protein, modulates the action of an important gene in the process ...

User comments : 0