Premium car research & cow dung point to new high tech disease diagnosis

Oct 12, 2009

(PhysOrg.com) -- Research at the University of Warwick have taken high tech gas sensors normally used to test components for premium cars and applied the same techniques to human blood,  human urine, and even cow dung samples from local cow pats. The results could lead to a new high tech medical tool that could provide a fast diagnosis for some of the most difficult gastrointestinal  illnesses and metabolic diseases

Researchers at the University of Warwick have taken gas sensors normally used to test components for premium cars and applied the same techniques to human blood, human urine, and even cow dung samples from local cow pats. The results could lead to a new high tech medical tool that could provide a fast diagnosis for some of the most difficult gastrointestinal illnesses and .

Fermentation of undigested foods in the colon by its resident bacteria affects not only colonic health (protection against inflammation and tumour formation) but also influences metabolic health. Studying fermentation and the volatile organic compounds (VOCs) it generates directly is difficult due to lack of easy access to the colon.

This video is not supported by your browser at this time.

Researchers from the University of Warwick’s innovation specialists WMG have devised a solution to this problem using a special suite of equipment normally used to test car components for premium cars. The equipment heats car material samples to see what range of “volatile chemicals” (essentially gases) are emitted from car components to understand what implications that would have for air quality in the car and how it might affect the future recycling of the component. The car researchers wondered if this high tech equipment for studying volatile chemicals in premium cars would also assist their medical colleagues seeking to study volatile organic compounds from the human colon.

The University of Warwick WMG researchers Dr Mark Pharaoh and Dr Geraint J. Williams invited medical consultant Dr Ramesh P Arasaradnam (a Clinician Scientist and Lecturer in Gastroenterology in Warwick Medical School and a Gastroenterologist at University Hospitals Coventry & Warwick) to work with them to advise on how they could test their equipment on organic matter. Professors Sudesh Kumar, Chuka Nwokolo and K D Bardhan, from Warwick Medical School, also joined the team.

The gas products of fermentation include various , the relative proportions of which may change in disease. The research team have coined the term ‘fermentome’ to describe the complex interplay between diet, symbiont bacteria and volatile gases The clinical researchers in the team believed that the research engineer’s equipment could help them study such a ‘fermentome’ which could then be used for diagnosis and disease characterisation. Measurement of VOCs through non-invasive methods could then have an important application as a hypothesis-generating tool and could even have clinical applications.

The joint clinician and engineering research team have now performed tests using the car analysis equipment on human blood, human urine, and even cow and horse dung harvested from locality. The results so far suggest that the equipment could indeed be used to obtain a useful picture of the range of fermentation gases produced by this organic matter. Knowing what those mix of gases are could therefore provide a useful analogue understanding of what gastrointestinal illness or metabolic diseases are afflicting patient.

The team have just published that research in a paper entitled “Colonic fermentation - More than meets the nose” in the journal Med Hypotheses. The research team are now exploring funding options that would allow them to take this new technique into a larger scale studies including clinical trials.

Dr Mark Pharaoh said:

“These early results suggest that we could indeed use this automotive technology to give medical consultants a very precise understanding of the mix of gasses being produced within the human gut. An understanding of the precise mix of gasses is a very valuable clue to understanding any problem with the balance and mix of bacteria that are generating those gases.”

Dr Ramesh P Arasaradnam said:

“This is could be a vital new tool in the diagnosis of gastrointestinal as well as metabolic diseases. Gaining first hand information of what is going on in the gut would require very invasive procedures. Even simply culturing the bacteria from a patient’s urine or faeces takes a considerable amount of time. This technique could give medical consultants such as myself valuable information about what is causing a patient’s condition long before the data from a standard bacterial culture would be available.”

The research team are now exploring funding options that would allow them to take this new technique into a clinical trial.

Provided by University of Warwick (news : web)

Explore further: Desktop device to make key gun part goes on sale in US

add to favorites email to friend print save as pdf

Related Stories

Car Buyers Say Silence Isn't Golden

Jul 12, 2005

The technology improvements that are giving us ever quieter cars are not proving popular with many car drivers. Car manufacturers now want to restore to the inside of a car the sounds their customers want ...

Recommended for you

Desktop device to make key gun part goes on sale in US

4 hours ago

The creator of the world's first 3D plastic handgun unveiled Wednesday his latest invention: a pre-programmed milling machine that enables anyone to easily make the core component of a semi-automatic rifle.

Minimally invasive surgery with hydraulic assistance

10 hours ago

Endoscopic surgery requires great manual dexterity on the part of the operating surgeon. Future endoscopic instruments equipped with a hydraulic control system will provide added support during minimally ...

Analyzing gold and steel – rapidly and precisely

12 hours ago

Optical emission spectrometers are widely used in the steel industry but the instruments currently employed are relatively large and bulky. A novel sensor makes it possible to significantly reduce their size ...

More efficient transformer materials

12 hours ago

Almost every electronic device contains a transformer. An important material used in their construction is electrical steel. Researchers have found a way to improve the performance of electrical steel and ...

Sensor network tracks down illegal bomb-making

12 hours ago

Terrorists can manufacture bombs with relative ease, few aids and easily accessible materials such as synthetic fertilizer. Not always do security forces succeed in preventing the attacks and tracking down ...

Miniature camera may reduce accidents

13 hours ago

Measuring only a few cubic millimeters, a new type of camera module might soon be integrated into future driver assistance systems to help car drivers facing critical situations. The little gadget can be ...

User comments : 0